Recently, multiple studies have shown that PDGF-D plays a critical role in governing Epithelial-to-Mesenchymal Transition (EMT), although the underlying mechanism of PDGF-D-mediated …

2011年4月21日 · We have identified the transcription factor Sox9 as a downstream target of PDGF-stimulated EMT. Our data show that Sox9 could rescue the EMT defect seen in PDGF …

Additionally, PDGF induces the phosphorylation of the nuclear RNA helicase p68, which promotes EMT through the nuclear translocation of β-catenin in a Wnt-independent manner in various …

2024年1月6日 · 转化型的cafs表达上调的emt相关基因和pdgfrα，其被pdgf-bb激活，并帮助原发肿瘤细胞侵犯血管并释放ctcs。抗pdgf药物伊马替尼可以在高pdgf-bb分泌的微环境中保持外包膜 …

2017年2月7日 · In addition, PDGF-D expression promoted Epithelial to mesenchymal transition (EMT), which was accompanied with decreased E-cadherin and increased Vimentin …

Studies have shown that platelet-derived growth factor (PDGF) signaling contributes to EMT, and more recently, PDGF-D has been shown to regulate cancer cell invasion and angiogenesis. …

2023年5月1日 · EMT is known to be induced by the transcription factor Twist1, and Twist1 also promotes PDGFR expression. The direct transcriptional target of Twist1 is PDGFRα. They …

Epithelial-mesenchymal transition (EMT) is important in the metastasis of tumours and is triggered by several key growth factors, including platelet-derived growth factor-B (PDGF-B). But, …

2006年11月20日 · Upon EMT, TGF- β induces the secretion and autocrine regulation of platelet-derived growth factor (PDGF) by upregulation of PDGF-A and both PDGF receptors. Here, we …

Recently, multiple studies have shown that PDGF-D plays a critical role in governing epithelial-to-mesenchymal transition (EMT), although the underlying mechanism of PDGF-D-mediated …