2022年3月17日 · Using pharmacological inhibitors, we dissected distinct aspects of the PDGF-BB response that are controlled by extracellular signal-regulated kinase (ERK) and Akt pathways. PDGF-BB promotes...

2012年7月13日 · First, we confirmed the role of PDGF-A-activated ERK signaling in OPC migration using the pharmacological inhibitor U0126, or siRNA-mediated suppression of ERK expression. Then, we demonstrated that PDGF-A-induced actin reorganization and interaction of focal adhesion kinase (FAK), Paxillin, and pERK signals are impaired in OPCs treated with ...

细胞外信号调节激酶（erk）信号的激活是pdgf-a诱导opc迁移的机制之一。 但是，PDGF-A诱导的ERK驱动的OPC迁移的机制仍不清楚。 在目前的研究中 我们进一步研究了PDGF-A诱导的ERK信号在OPC迁移中的作用。

2021年8月4日 · Our data demonstrated that PDGF-BB directly regulated the expression of TH via activating the downstream Akt/ERK/CREB signaling pathways. Our finding will further support the therapeutic potential of PDGF-BB in PD, and provide the possibility that targeting PDGF signaling can be harnessed as an adju …

The results showed that PDGF-BB significantly increased PRMT1 expression after 1h lasting over 48h, through ERK1/2 MAPK and STAT1 signaling. The inhibition of ERK1/2 MAPK or of PRMT1 activity decreased PDGF-BB induced fibroblast proliferation, COX2 production, collagen-1A1 secretion, and fibronectin production.

2012年7月14日 · PDGF-BB activation of PDGFRβ causes sustained Akt and transient Erk phosphorylation. To investigate further the downstream pathways involved in PDGF-BB stimulation of MSC proliferation, we assessed the alteration in phosphorylation of PDGFRβ, SHP2, Akt and P44/P42 MAPK in response to stimulation with PDGF-BB.

2009年7月16日 · Our data indicate that αvβ5 synergizes with two distinct signalling pathways, through a tyrosine kinase receptor (PDGF receptor-β) and a G-protein-coupled receptor (CXCR4), to promote ERK ...

2005年7月8日 · Cyclin-dependent kinase inhibitor p27, a critical determinant for cellcycle progression, is an important regulation target of mitogenic signalsduring arterial injury. In this study, we show in rat aortic smooth musclecells that PDGF-BB down-regulated p27 protein and mRNA in an ERK-dependentmechanism.

2025年1月11日 · 实验结果显示，PDGF-D能够显著促进肺癌细胞的增殖，而ERK通路的激活是其中关键因素之一。 通过Western blot检测发现，PDGF-D处理后，肺癌细胞中ERK通路的磷酸化水平明显升高，而抑制ERK通路的活性可以显著降低PDGF-D对肺癌细胞增殖的促进作用。 2. PDGF-D对肺癌细胞迁移和侵袭的影响. PDGF-D还能够促进肺癌细胞的迁移和侵袭。 通过划痕实验和Transwell小室实验发现，PDGF-D处理后，肺癌细胞的迁移和侵袭能力明显增强。 而抑 …

结果:1.内皮抑素预处理可以抑制pdgf-bb或tgf-β1诱导的成纤维细胞Ⅰ型胶原、α-sma蛋白表达。 2.内皮抑素通过抑制p-PDGFRβ,PDGFRβ,p-ERK表达调控成纤维细胞增生。