The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction.

2024年12月25日 · PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a Protein Coding gene. Diseases associated with PDGFRA include Gist-Plus Syndrome and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

2015年12月7日 · Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) in this process.

Pdgfrα + stromal cells participate in degeneration and regeneration in varieties of tissues and organs. They share similarities and have unique and important features. Pdgfrα + stromal cells in most tissues play a “double-edged sword" effect.

2024年2月29日 · PDGFRα + ITGA11 + CAFs significantly decreased VE-cadherin expression in lymphatic vessels and increased the lymphangiogenesis and formation of LVI in primary BCa tissues, while the administration of PP2 attenuated these effects (Figures 5Q and S7J–S7L).

Platelet-Derived Growth Factor Receptor Type alpha Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension. EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma.

PDGFRα signaling controls gastrulation and the development of several organs such as lung, intestine, skin, testis, kidney, bones, and neuroprotective tissues. PDGFRβ signaling is better recognized as an essential regulator of early hematopoiesis and blood vessel formation [3].

We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge. In total, this review provides a conclusive summary on the state of the PDGFR field and underscores the need for novel techniques to fully elucidate the mechanisms of PDGFR activation, internalization and signal ...

2009年2月17日 · We have generated conditional knockin mice with mutations in PDGFRα that drive increased kinase activity under the control of the endogenous PDGFRα promoter. In embryos, increased PDGFRα signaling leads to hyperplasia of stromal fibroblasts, which disturbs normal smooth muscle tissue in radially patterned organs.

2023年5月1日 · The platelet derived growth factor receptor alpha (PDGFRα) has been regarded as a significant factor in the growth, angiogenesis, and spread of metastatic tumours. It served as a target for tyrosine kinase (TK) inhibitors that were developed for …

2 天之前 · Immunoblot analysis of total PDGFRα, phosphorylated PDGFRα (p-PDGFRα), total S6, and phosphorylated S6 (p-S6) protein expression after 3 days of avapritinib treatment in BT245 and PPK cells. Immunoblot images have been cropped to show samples of interest and to align lanes. Representative images of one to two biological replicates are shown.

2019年8月1日 · Platelet-derived growth factor receptor α (PDGFRα), a receptor tyrosine kinase required for cardiac fibroblast development, is uniquely expressed by fibroblasts in the adult heart. Despite the consensus that PDGFRα is expressed in adult cardiac fibroblasts, we know little about its function when the …

2025年3月1日 · In this review, we summarize previous and current findings on Pdgfrα + stromal cells in various tissues and discuss the crosstalk between Pdgfrα + stromal cells and microenvironment. Extracellular matrix (ECM) remodeling occurs in tissue regeneration, repair, and degeneration.

2020年1月14日 · We show that PDGFRα + cells are essential for tissue revascularization and restructuring through injury-stimulated remodeling of stromal and vascular components, context-dependent clonal expansion, and ultimate removal of pro-fibrotic PDGFRα + -derived cells.

2015年12月7日 · Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) in this process.

PDGFR α has long been recognised for its roles in the mesoderm formation and connective tissue development during the embryogenesis. Current review describes the lines of evidence regarding the role of PDGFR α in morphogenesis and differentiation and its implications for MSC biology. 1. PDGFR α and Mesenchymal Stem Cells.

Platelet-derived growth factor receptor alpha (PDGFRα) is a receptor tyrosine kinase that undergoes dimerization and autophosphorylation upon ligand (PDGF) binding, thereby activating several major signal transduction cascades, including the PI3K/Akt and the Ras-MAPK pathways, which in turn mediate important cell functions such as migration ...

We show that PDGFRα + cells are essential for tissue revascularization and restructuring through injury-stimulated remodeling of stromal and vascular components, context-dependent clonal expansion, and ultimate removal of pro-fibrotic PDGFRα + -derived cells.

Pdgfra -expressing (Pdgfra+) cells have been implicated as progenitors in many mesenchymal tissues. To determine lineage potential, we generated PdgfrartTA knockin mice using CRISPR/Cas9.

2022年8月16日 · Platelet-derived growth factor (PDGF) promotes tissue repair and fibrosis, but the relationship between PDGF and myofibroblasts is unclear. Using mice with lineage tracing linked to PDGF receptor α (PDGFRα) gene mutations, we …