The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases …

2024年12月25日 · PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a Protein Coding gene. Diseases associated with PDGFRA include Gist-Plus Syndrome and Gastrointestinal …

2015年12月7日 · Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) …

Pdgfrα + stromal cells participate in degeneration and regeneration in varieties of tissues and organs. They share similarities and have unique and important features. Pdgfrα + stromal cells …

2024年2月29日 · PDGFRα + ITGA11 + CAFs significantly decreased VE-cadherin expression in lymphatic vessels and increased the lymphangiogenesis and formation of LVI in primary BCa …

Platelet-Derived Growth Factor Receptor Type alpha Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension. EPHA2 …

PDGFRα signaling controls gastrulation and the development of several organs such as lung, intestine, skin, testis, kidney, bones, and neuroprotective tissues. PDGFRβ signaling is better …

We further highlight the commonalities and differences between PDGFRα and PDGFRβ signaling, revealing critical gaps in knowledge. In total, this review provides a conclusive summary on the …

2009年2月17日 · We have generated conditional knockin mice with mutations in PDGFRα that drive increased kinase activity under the control of the endogenous PDGFRα promoter. In …

2023年5月1日 · The platelet derived growth factor receptor alpha (PDGFRα) has been regarded as a significant factor in the growth, angiogenesis, and spread of metastatic tumours. It served …

2 天之前 · Immunoblot analysis of total PDGFRα, phosphorylated PDGFRα (p-PDGFRα), total S6, and phosphorylated S6 (p-S6) protein expression after 3 days of avapritinib treatment in …

2019年8月1日 · Platelet-derived growth factor receptor α (PDGFRα), a receptor tyrosine kinase required for cardiac fibroblast development, is uniquely expressed by fibroblasts in the adult …

2025年3月1日 · In this review, we summarize previous and current findings on Pdgfrα + stromal cells in various tissues and discuss the crosstalk between Pdgfrα + stromal cells and …

2020年1月14日 · We show that PDGFRα + cells are essential for tissue revascularization and restructuring through injury-stimulated remodeling of stromal and vascular components, …

2015年12月7日 · Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) …

PDGFR α has long been recognised for its roles in the mesoderm formation and connective tissue development during the embryogenesis. Current review describes the lines of evidence …

Platelet-derived growth factor receptor alpha (PDGFRα) is a receptor tyrosine kinase that undergoes dimerization and autophosphorylation upon ligand (PDGF) binding, thereby …

We show that PDGFRα + cells are essential for tissue revascularization and restructuring through injury-stimulated remodeling of stromal and vascular components, context-dependent clonal …

Pdgfra -expressing (Pdgfra+) cells have been implicated as progenitors in many mesenchymal tissues. To determine lineage potential, we generated PdgfrartTA knockin mice using …

2022年8月16日 · Platelet-derived growth factor (PDGF) promotes tissue repair and fibrosis, but the relationship between PDGF and myofibroblasts is unclear. Using mice with lineage tracing …