Activation of pyruvate dehydrogenase by dichloroacetate has the ...
Dichloroacetate (DCA) promotes pyruvate entry into the Krebs cycle by inhibiting pyruvate dehydrogenase (PDH) kinase and thereby maintaining PDH in the active dephosphorylated …
Sodium dichloroacetate (二氯乙酸钠) - 仅供科研 | PDHK 抑制剂
Sodium dichloroacetate 抑制丙酮酸脱氢酶激酶 (PDHK)，从而导致肿瘤微环境中的乳酸减少。 Sodium dichloroacetate 增加活性氧 (ROS) 的产生并促进癌细胞凋亡，还可作为 NKCC 抑制剂 …
Cell Reports丨丙酮酸脱氢酶激酶在急性炎症期间支持巨噬细胞 …
为了检查 PDHK 抑制对巨噬细胞 NLRP3 炎性体激活的影响，作者使用了两种 PDHK 药理学抑制剂：DCA 和 JX06。 DCA 通过与丙酮酸激酶口袋结合来阻断所有四种 PDHK 亚型。 相比之 …
Primary Pyruvate Dehydrogenase Complex Deficiency Overview
2021年6月17日 · Primary pyruvate dehydrogenase complex deficiency (PDCD) is a mitochondrial disorder of carbohydrate oxidation that mostly affects the brain and leads to decreased ATP …
Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, …
2022年2月1日 · Pyruvate dehydrogenase (PDH) catalyzes the decarboxylation of pyruvate to acetyl-CoA, which plays a key role in linking cytosolic glycolysis to mitochondria metabolism. …
Regulating mitochondrial metabolism by targeting pyruvate …
2023年10月1日 · DCA is a naturally occurring molecule that modulates mitochondrial metabolism. DCA inhibits PDK, activating PDC and promoting oxidative phosphorylation. Treatment with …
The PDK1 Inhibitor Dichloroacetate Controls Cholesterol
2017年9月6日 · In this sense, dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, augments usage of the glycolysis-produced pyruvate in the mitochondria increasing …
DCA Protects against Oxidation Injury Attributed to Cerebral …
2021年10月19日 · This study adopted a transient middle cerebral artery occlusion (MCAO) mouse model for simulating IS and I/R injury in mice. We investigated the mechanism by which DCA …
丙酮酸脱氢酶与肿瘤 - 仁和软件
肿瘤细胞偏向于糖酵解获取能量，部分是由 于肿瘤细胞中pdk活性上调而抑制了pdh的活 性。研究显示通过二氯乙酸（dca）靶向抑制 pdk促进了肿瘤细胞的代谢形式由糖酵解转化为 氧化磷酸 …
Dichloroacetate, a pyruvate dehydrogenase activator, alleviates …
2024年11月6日 · Pyruvate dehydrogenase (PDH) plays a crucial role in glucose metabolism and is associated with muscle differentiation. However, the effect of dichloroacetate (DCA), a PDH …