Increased oxidative phosphorylation through pyruvate …
2025年2月3日 · Researchers focused on PDK2, a protein that inactivates PDH, thereby reducing OxPhos activity in chondrocytes. They used mice genetically modified to lack PDK2 and …
Pyruvate and uridine rescue the metabolic profile of OXPHOS …
2022年9月1日 · OXPHOS dysfunction has a unique metabolic signature linked to an NAD+/NADH imbalance including depletion of TCA intermediates and aspartate, and increased levels of …
Increased oxidative phosphorylation through pyruvate …
2025年2月3日 · PDK2 deficiency partially restored OxPhos in IL-1β-treated chondrocytes, leading to increases in APT and the NAD + /NADH ratio. These metabolic changes were accompanied …
Hypoxia-inducible factor-1α shifts metabolism from oxidative ...
2020年9月15日 · To further elucidate the relationship between AjHIF-1α and glycolysis in sea cucumbers, we detected the changes in the mRNA expression levels of glycolytic genes, …
Mitochondrial hydrogen peroxide production by pyruvate …
2023年12月1日 · The keto acid dehydrogenases PDH and KGDH occupy pivotal positions in mitochondrial bioenergetics as both enzymes connect monosaccharide and amino acid …
线粒体丙酮酸脱氢酶激酶通过调节有氧糖酵解促进小鼠血小板功能 …
Mitochondrial enzymes pyruvate dehydrogenase kinases (PDKs) phosphorylate the pyruvate dehydrogenase (PDH) complex to inhibit its activity, thereby diverting the pyruvate flux from …
Phosphorylation of the pyruvate dehydrogenase complex …
The pyruvate dehydrogenase complex (PDC) is an important gatekeeper enzyme connecting glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). …
Mitochondrial pyruvate dehydrogenase kinases contribute to …
2023年6月13日 · Mitochondrial enzymes pyruvate dehydrogenase kinases (PDKs) phosphorylate the pyruvate dehydrogenase (PDH) complex to inhibit its activity, thereby diverting the …
Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative ...
2023年7月20日 · Here, we report that pyruvate metabolism and oxidative phosphorylation pathway is enriched in OA cartilage through gene set enrichment analysis (GSEA) and …
The Synergistic Impact of Glycolysis, Mitochondrial OxPhos, and …
The end products of glycolysis, PEP and pyruvate, serve as key sources of ATP: PEP is directly converted into pyruvate via PK, generating ATP locally, while pyruvate is channeled into the …