PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways activated by several growth factors and hormones including insulin signaling.

2024年12月25日 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease. Among its related pathways are Regulation of pyruvate metabolism and ESR-mediated signaling.

PDK-1 (3-Phosphoinositide-dependent protein kinase 1), a member of the protein A, G and C (AGC) family of proteins, is a Ser/Thr protein kinase. PDK-1, is the pivotal node in the PI3K pathway, has a key role in insulin and growth-factor signalling through phosphorylation and subsequent activation of a number of other AGC kinase family members ...

2022年4月6日 · PDK1 (3-phosphoinositide-dependent kinase 1) is a serine/threonine-protein kinase that plays a central role in regulating cell growth, survival, and proliferation....

丙酮酸脱氢酶激酶 1： 丙酮酸脱氢酶 (pdh) 是一种线粒体多酶复合物，可催化丙酮酸的氧化脱羧作用，是负责调节哺乳动物碳水化合物燃料稳态的主要酶之一。

2025年1月4日 · Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle.

2008年6月10日 · Here we describe the expression and function of a HIF-1-regulated protein pyruvate dehydrogenase kinase-1 (PDK-1) in head and neck squamous cancer (HNSCC). Using RNAi to downregulate...

3-磷酸肌醇依赖性蛋白激酶1(pdk1)是磷脂酰肌醇3激酶-蛋白激酶b(pi3k-akt)通路的一个关键调节分子。 PDK1可通过激活Akt，参与PI3K-Akt信号通路的活化，促进肿瘤的发生、发展及浸润转移。

丙酮酸脱氢酶激酶 1： 该基因编码的蛋白可启动 atp 绑定活动；相同的蛋白质结合活性；和蛋白激酶活性。 参与细胞表面受体信号通路和肽基丝氨酸磷酸化。

2019年6月28日 · pdk-1在调节细胞迁移中具有重要作用，特别是在pdk-1缺乏的情况下。 PDK-1是有效的治疗靶标，并且表明PDK-1抑制剂可用于预防癌症进展和异常组织传播。 cas号查询