PNAS∣编码丙酮酸磷酸双激酶的玉米基因在发育胚乳中的功能研究
Direct targets of the bZIP transcriptional regulator encoded by o2 include pdk1 and pdk2 that specify pyruvate phosphate dikinase (PPDK). This enzyme reversibly converts AMP, …
Pyruvate dehydrogenase kinases (PDKs): an overview toward …
PDK1, as an important direct target for metabolism, inhibits pyruvate flux to mitochondrial respiration. A rescue of PDK1 expression in Wnt-inhibited cancer cells rescues glycolysis as …
Activation of the essential kinase PDK1 by phosphoinositide …
2022年4月6日 · 3-phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein kinase, which plays a crucial role in cell growth and proliferation. It is...
Cell Metabolism | 细胞代谢的分子机制如何做？代谢顶刊CM的这篇 …
PDK不同剪切异构体中，PDK4显著促进EMT，PDK3对EMT有一定的促进作用，而PDK1和PDK2对EMT没有影响（图2C-D）。 作者在PDK4启动子区找到了四个TGF-β信号通路转录因 …
The Glycolytic Gatekeeper PDK1 defines different metabolic states ...
2022年3月1日 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML). PDK1 …
PDK1 Gene - GeneCards | PDK1 Protein | PDK1 Antibody
2024年12月25日 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …
PI3K-AKT通路专题解析（下） - 知乎专栏
丝氨酸/苏氨酸激酶 AKT（又称作蛋白激酶 B 或Protein kinase B, PKB）作为一种原癌基因，已经成为医学界主要的关注热点，这是因为它在调控各种不同细胞功能（包括代谢、生长、增殖、 …
Pyruvate dehydrogenase kinase 1 protects against neuronal injury …
2023年11月7日 · Research showed that Aβ-resistant nerve cells displayed increased PDK1 expression, enhanced lactate dehydrogenase A (LDHA) activity and reduced mitochondrial …
3-磷酸肌醇依赖性蛋白激酶1 结构和功能 - 道客巴巴
2013年9月16日 · 许多研究显示， PDK1(3-phosphoinositide-dependent proteinkinase-1, PDK1)是 PKB、 S6K、 RSK和 PKC 等 AGC激酶活化环的主要激酶[1]。 从分离纯化并被鉴定为PKBα …
PDK1: At the crossroad of cancer signaling pathways
2018年2月1日 · This review analyzes the up-to-date knowledge supporting PDK1 involvement in altered signaling in cancer, what cancer types and subtypes would benefit from a PDK1 …