Cell Metabolism | 细胞代谢的分子机制如何做？代谢顶刊CM的这篇 …
敲低pdk4显著抑制pdh磷酸化并上调ac-coa（图2a-b）。 PDK不同剪切异构体中，PDK4显著促进EMT，PDK3对EMT有一定的促进作用，而PDK1和PDK2对EMT没有影响（图2C-D）。
PDK4 rescues high-glucose-induced senescent fibroblasts and
2023年11月25日 · PDK4, in our study, phosphorylated PDH and reduced its activity, thereby inhibiting mitochondrial respiration and subsequently decreasing ROS generation. Additionally, …
Nature Metabolism | 新知识：糖代谢调控因子影响肿瘤生长和生理 …
这篇文章于2023年10月发表在 Nature Metabolism （IF=20.8， PDK4 -dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy），是 …
PDK4-dependent hypercatabolism and lactate production of
2023年10月30日 · In this Article, we aimed to characterize the senescence-associated metabolism and uncovered that that pyruvate dehydrogenase kinase isoform 4 (PDK4), a …
Pyruvate dehydrogenase kinases (PDKs): an overview toward …
Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …
Down-regulation of PDK4 is Critical for the Switch of ... - Nature
2017年8月16日 · By using primary human trophoblasts, we demonstrated that PDK4 was the dominating PDK isoform in human cytotrophoblasts, and its abundance was substantially …
Role of pyruvate dehydrogenase kinase 4 in regulating PDH …
The oxidation of carbohydrates in mammals is regulated by the pyruvate dehydrogenase (PDH) complex, which is covalently regulated by four PDH kinases (PDK1-4) and two PDH …
Pyruvate Dehydrogenase Kinase 4 - an overview - ScienceDirect
Pyruvate dehydrogenase kinase 4 (PDK4) is a regulator of PDH, as it inhibits PDH activity, which in turn will increase the influx of acetyl-coA from beta-oxidation into the TCA cycle, thereby …
Pyruvate dehydrogenase kinase regulates vascular inflammation in ...
2023年7月4日 · Pyruvate dehydrogenase kinase (PDK)-dependent inhibition of pyruvate dehydrogenase (PDH) has been identified as a major metabolic step regulating inflammation. …
PDK4 dictates metabolic resistance to ferroptosis by suppressing ...
2021年2月23日 · Screening of a small interfering RNA (siRNA) library targeting metabolic enzymes leads to identification of pyruvate dehydrogenase kinase 4 (PDK4) as the top gene …