Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. [1] It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from a patient.

人源性组织异种移植 (patient-derivedxenografts , PDX) [1] 模型是一种将肿瘤患者的肿瘤组织移植至 重症免疫缺陷型小鼠 (NSG)体内,并使肿瘤组织在小鼠体内生长形成第一代 移植瘤 （图 1）。 待其生长到一定大小时，取出该移植瘤组织并在无菌操作条件下移植到新一批小鼠体内，形成第二代移植瘤。 如此重复操作形成移植瘤第三代、第四代等。 此种模型尽可能保留了亲代肿瘤的生长微环境，利于更好的表现亲代肿瘤性状，并且维持了肿瘤的异质性。 但同时也存在两个主要的 …

2023年4月12日 · Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in...

2020年1月8日 · 人源性肿瘤异种移植模型 (Patient-derived Tumor Xenograft Model，PDX) 是将患者肿瘤组织直接接种于免疫缺陷小鼠而建立的新型肿瘤研究模型，该模型保留了其供体肿瘤的主要组织学和遗传学特征，能够在后续传代中保持稳定，是一种能与临床样本保持较高一致性，且 ...

PDX models simulate human tumor biology allowing for natural cancer progression and offer the most translational research model for evaluating efficacy. Determine which PDX model is best for your studies

Over 300 patient-derived xenograft (PDX) tumors are available for engrafting into immunocompromised NSG™ mice for shipment to your facility or use in JAX-directed preclinical efficacy studies.

Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models.

PDX models are anticipated to efficiently bridge non-clinical and clinical data in translational research. Based on the evidence obtained from our research experience, this review describes the characteristics of PDX models for acting as tumor models, and elucidates the points to consider when attempting to establish these models.

The PDMR also accepts previously derived PDX models developed at external sites. The features and services of the PDMR are as follows: Target of 1000 clinically-annotated early-passage patient-derived xenografts (PDXs) from tumor specimens …

Discover the largest catalog of patient-derived xenograft, organoid, and cell cancer models for your next project.