2021年1月28日 · Early passage cell strains showed high consistency between patient and PDX tumors. Together, these data describe a robust human xenograft model system for investigating NSCLC brain metastases.

2023年4月12日 · Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority...

2021年8月24日 · Here, we report on dynamic genomic landscapes and pharmacogenomic associations, including associations between activating oncogenic events and drugs, correlations between whole-genome duplications...

The PDMR also accepts previously derived PDX models developed at external sites. The features and services of the PDMR are as follows: Target of 1000 clinically-annotated early-passage patient-derived xenografts (PDXs) from tumor specimens …

2020年10月5日 · The PDMR assesses every passage for the presence of xenograft-associated lymphoproliferative disorders (XALDs). We group the following PDX-associated issues into this classification for simplicity: human lymphoma outgrowth, murine tumor outgrowth, murine lymphoma outgrowth, and graft-versus-host disease (GvHD).

2020年6月1日 · Patient-derived xenografts (PDXs) are obtained by transplanting fragments of a patient’s tumour into immunodeficient mice. Growth and propagation of PDXs allows correlating therapeutic response in vivo with extensive, multi-dimensional molecular annotation, leading to identification of predictive biomarkers.

2022年12月16日 · This protocol describes how to generate an acquired resistance humanized in vivo model to immunotherapies in patient-derived xenografts (PDX). We detail steps to inject human CD34 + cells into NSG mice, followed by generation of immunoresistant PDX in humanized mice.

2020年7月28日 · PASSAGE NUMBERS OF PDX MODELS USED IN STUDIES AND HUMANIZED PDX MODELS. Regarding the passage numbers of the PDX models used by the 19 academic researchers who answered "PDX models used" and "anticancer drugs developed," where the passage number at the time of establishment is set as P0, the 1st passage (P1) was used by 4 (9.3%), the 2nd ...

2021年2月18日 · We describe an androgen-dependent PCa patient-derived xenograft (PDX) model from treatment-naïve, soft tissue metastasis (PNPCa). RNA and whole-exome sequencing of the PDX tissue and organoids...

2024年7月16日 · Comprehensive profiling of matched PDX and patient samples demonstrates that PDXs closely recapitulate parental tumors. By leveraging multi-lineage models, we reveal that the previously reported genomic disparities of PDX could be mainly attributed to intra-patient spatial heterogeneity instead of substantial model-independent genomic evolution.