PE11, a PE/PPE family protein of Mycobacterium tuberculosis is ... - PubMed
2016年2月23日 · One of the PE family proteins, PE11 (LipX or Rv1169c), specific to pathogenic mycobacteria is found to be over-expressed during infection of macrophages and in active TB patients. In this study, we report that M. smegmatis expressing PE11 (Msmeg-PE11) exhibited altered colony morphology and cell wall lipid composition leading to a marked ...
Structure-function relationship of PE11 esterase of Mycobacterium ...
2024年12月20日 · The lipolytic enzymes of Mycobacterium tuberculosis play a critical role in immunomodulation and virulence. Among these proteins, PE11 which also belongs to the PE/PPE family, is the smallest (∼10.8 kDa) and play a significant role in cell wall remodelling and virulence. PE11 is established to be an …
Structure-function relationship of PE11 esterase of
2024年12月20日 · PE11 esterase activity is responsible for better survival of mycobacteria. PE11 may be targeted to develop suitable therapeutics against tuberculosis. The lipolytic enzymes of Mycobacterium tuberculosis play a critical role in immunomodulation and virulence.
PE11, a PE/PPE family protein of - Nature
2016年2月23日 · In this study, we report that M. smegmatis expressing PE11 (Msmeg-PE11) exhibited altered colony morphology and cell wall lipid composition leading to a marked increase in resistance against...
Down-regulation of PE11, a cell wall associated esterase, enhances …
2017年1月1日 · PE11 (Rv1169c or LipX) is a cell wall associated esterase/lipase of Mycobacterium tuberculosis (Mtb). Evidences suggest that PE11 is expressed by Mtb both in vitro and in vivo. Previous studies have shown that PE11 leads to modification in cell wall lipid content and enhanced virulence when expressed in the non-pathogenic surrogate ...
Down-regulation of PE11, a cell wall associated esterase ... - PubMed
PE11 (Rv1169c or LipX) is a cell wall associated esterase/lipase of Mycobacterium tuberculosis (Mtb). Evidences suggest that PE11 is expressed by Mtb both in vitro and in vivo. Previous studies have shown that PE11 leads to modification in cell wall lipid content and enhanced virulence when expresse …
In this study, we report that M. smegmatis expressing PE11 (Msmeg-PE11) exhibited altered colony morphology and cell wall lipid composition leading to a marked increase in resistance against...
(PDF) PE11, a PE/PPE family protein of Mycobacterium
2016年2月23日 · In this study, we report that M. smegmatis expressing PE11 (Msmeg-PE11) exhibited altered colony morphology and cell wall lipid composition leading to a marked increase in resistance against...
PE11 (Rv1169c) selectively alters fatty acid components of
2015年6月23日 · M. tuberculosis Rv1169c encodes for PE11, a prototypical member of PE/PPE family protein, was characterized in this study. The up-regulation of Rv1169c after 24 h of starvation (Betts et al., 2002 ) or transient acid exposure (Fisher et al., 2002 ), suggested a role in pathogen persistence or dormancy, in particular, in fatty acid metabolism.
PE11（一种细胞壁相关酯酶）的下调可增强结核分枝杆菌的生物膜 …
PE11（Rv1169c 或 LipX）是结核分枝杆菌 (Mtb) 的细胞壁相关酯酶/脂肪酶。 有证据表明，PE11 在体外和体内均由 Mtb 表达。 以前的研究表明，当 PE11 在非致病性替代品耻垢分枝杆菌中表达时，会导致细胞壁脂质含量的改变和毒力增强。