Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. [5] [6] PepT 1 is a solute carrier for …

2019年3月21日 · 对于很多口服吸收差的药物，以肠道转运体PepT1 为靶点，按照底物结构特征的要求 对药物分子进行结构修饰，可大大提高药物的跨膜吸收，改善其体内药动学性质，进而 …

2018年3月25日 · The peptide transporter 1 (PepT1, SLC15A1) is abundantly expressed particularly in the intestinal tract and provides highly effective transport of amino acids in the …

2021年11月3日 · Besides the uptake of short peptides, peptide transporter 1 (PepT1) is a highly abundant drug transporter in the intestine and represents a major route for oral drug delivery. …

寡肽转运蛋白1 (oligopeptide transporter 1,PepT1;solute carrier family 15 member 1,SLC15A1)是一种主要存在于小肠上皮细胞的质子依赖型转运蛋白质,转运底物主要为蛋白质水解产物中的 …

2023年10月21日 · 寡肽转运蛋白pept1在寡肽及拟肽类药物肠转运中发挥重要的作用，其能介导二肽或三肽类的吸收。pept1对底物识别的多专属性，使得以pept1为靶点设计载体前药提高药物 …

2013年12月1日 · PepT1 ablation resulted in a 23-fold reduction in peak plasma concentration and a 14-fold reduction in systemic exposure of cefadroxil after oral dosing [12 ••]. The authors …

When expressed in heterologous systems, the cloned transporter, known as PEPT1 (peptide transporter 1), mediates H +-coupled and electrogenic transport of dipeptides and tripeptides …

PEPT1 (most recently reviewed in [1] and [5]) is a high capacity, low affinity, sodium-independent symporter, or cotransporter, which catalyzes the electrogenic uphill transport of L-enantiomers …

2018年3月25日 · The peptide transporter 1 (PepT1, SLC15A1) is abundantly expressed particularly in the intestinal tract and provides highly effective transport of amino acids in the …