2020年4月22日 · The prefrontal cortex (PFC) plays a critical role in regulating responses to stress in terms of the coordination of autonomic, neuroendocrine, and behavioral processes to promote adaptation and survival (Arnsten, 2009, McEwen and Morrison, 2013, McKlveen et al., 2015).

2022年3月31日 · Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain activity. However, the whole-brain organization of PFC axon projections...

2023年9月4日 · We demonstrate through a combination of electrophysiological, chemogenetic, optogenetic, calcium recording, and gene silencing techniques that the release of CRH from ILA neurons (ILA CRH neurons) into the rostral region of LS …

2021年11月2日 · 一项研究发现，CeA中表达促肾上腺皮质激素释放激素（corticotropin releasing hormone, CRH）的神经元（CRHCeA）会投射至LC，化学遗传激活CRHCeA→LC投射显著增加小鼠焦虑样行为，并且使LC区域的c‑Fos表达水平增加 。

本研究采用眶下神经慢性压迫（Chronic constriction injury of infraorbital nerve，CION）方法构建三叉神经病理性痛小鼠模型，发现三叉神经损伤后2周出现明显的焦虑和抑郁样行为表型。 与慢性痛继发抑郁样行为出现的时间窗一致，小鼠内侧前额叶皮层（Medial prefrontal...

Using morphology, electrophysiology, and calcium imaging approaches, we characterized mPFC CRF neurons as a unique subtype of GABAergic inhibitory interneurons that were directly engaged in the tail suspension chal-lenge.

纽约大学Grossman医学院Jing Wang团队于2023年4月5日在Neuron发表原著论文，揭示了PVN投射到边缘前PFC（PL-PFC）的催产素能神经元通过增强PFC神经元活动发挥镇痛作用。

2017年10月9日 · Together, these expression patterns suggest an important role for the CRH system in PFC circuitry. The goal of the current study was to determine the cell type-specific expression of CRH-BP in the PFC to begin to define the neural circuits in which CRH-BP is acting.

2021年3月15日 · 促肾上腺皮质激素释放激素 (CRH) 是一种重要的神经调节剂，广泛分布于大脑中，在介导应激反应和自主神经功能中起关键作用。 虽然已经在不同的转基因小鼠品系中研究了荧光标记的 CRH 表达神经元的分布模式，但对这一群体的广泛多样性和局部神经连接的全面了解只能来自将单细胞形态信息整合为一个定义特征。 然而，单个 CRH 神经元的形态和由这些神经元形成的局部回路尚未在全脑和树突尺度水平上获得。 我们筛选了表达 EYFP 的 CRH-IRES …

5 天之前 · Chronic stress profoundly affects the structure and function of the prefrontal cortex (PFC), a brain region critical for executive functions and emotional regulation. This review synthesizes current knowledge on stress-induced PFC plasticity, encompassing structural, functional, and molecular changes.