Perfluorohexanesulfonic acid (PFHxS) (conjugate base perfluorohexanesulfonate) is a synthetic chemical compound. It is one of many compounds collectively known as per- and polyfluoroalkyl substances (PFASs).

EPA announced the release of the IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts (Public Comment and External Review Draft) for a 60-day public comment period and external peer review. The deadline for comments is September 22, 2023.

Two target sulfonic acids [PFOS and perfluorohexanesulfonic acid (PFHxS)], three non-target acids [perfluoropentanesulfonic acid (PFPeS), perfluoroheptanesulfonic acid (PFHpS), and perfluorononanesulfonic acid (PFNS)], and four unknown sulfonic acids (Cl-PFOS, ketone-PFOS, ether-PFHxS, and Cl-PFHxS) were exclusively or significantly more ...

PFHxS has been detected in groundwater in private drinking water wells and public drinking water systems in several parts of Minnesota where known industrial use or disposal of PFAS occurred.

2025年1月13日 · EPA has finalized the IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts. This assessment addresses the potential cancer and noncancer human health effects from exposure to PFHxS and related salts. EPA’s program and regional offices may use this assessment to inform decisions to protect human health.

Nov 2019: Systematic Review Protocol for the Perfluorohexanesulfonic Acid (PFHxS) IRIS Assessment (Preliminary Assessment Materials) (Report) Additional EPA toxicity information may be available by visiting the following sites:

Short-term exposures have the potential to stay in the body for an extended period of time. In addition, accumulated maternal PFHxS is transferred to offspring (i.e., placental and breastmilk transfer). A single HRL has therefore been recommended for …

Perfluorohexanesulfonic acid (PFHxS) is a highly prevalent environmental pollutant, often considered to be less toxic than other poly- and perfluoroalkyl substances (PFASs). Despite its relatively lower environmental impact compared to other PFASs, ...

Human epidemiological studies have examined possible associations between PFHxS exposure and health outcomes, including immune responses, birth weight, hematopoietic effects, thyroid hormone effects, liver enzyme effects, serum lipids effects, cardiovascular disease, hematological effects, reproductive effects, neurodevelopmental effects, and ca...

Indicator B6 presents median blood serum levels of PFOS, PFOA, PFHxS, and PFNA for women ages 16 to 49 years. About the Indicator: Indicator B6 presents concentrations of perfluorochemicals (PFCs) in blood serum of U.S. women ages 16 to 49 years.