Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
2013年2月1日 · In the present work, we have identified a novel mRNA of PFK-2/FBPase-2 specific of fetal liver that differs to L isoform by exon 1 L that contains sites for phosphorylation …
Phosphofructokinase 2 - Wikipedia
Phosphofructokinase-2 (6-phosphofructo-2-kinase, PFK-2) or fructose bisphosphatase-2 (FBPase-2), is an enzyme indirectly responsible for regulating the rates of glycolysis and …
The bifunctional 6-phosphofructokinase-2/fructose-2,6 …
2022年1月1日 · In mammalian PFK-2/FBPase-2, the protein kinase-dependent phosphorylation at isozyme-specific residues facilitates the modulation of Fru-2,6-P 2 levels in response to …
Nature Metabolism丨PFKFB2 介导的糖酵解促进巨噬细胞乳酸驱动 …
我们发现胞吐作用促进巨噬细胞糖酵解的短暂增加，这依赖于酶 6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶 2 (PFKFB2) 的快速激活，这将此过程与促炎巨噬细胞糖酵解区分开来 。 与野生型对照 …
Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor ...
The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFK-2/FBPase-2, PFKFB3) is a glycolysis regulatory enzyme and plays a key role in oncogenesis of several cancers. …
Transcriptional and posttranscriptional regulation of 6-phosphofructo-2 ...
2001年1月1日 · The control of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2; EC 2.7.1.105/3.1.3.46) gene expression during liver regeneration was studied. …
Mutation of regulatory phosphorylation sites in PFKFB2 …
2020年9月3日 · Phosphorylation of the kidney isoform, PFKFB2, on residues Ser 468 and Ser 485 stimulates glycolysis and is the most important mechanism regulating glycolysis. We …
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase ...
Fru-2,6-P 2 is a powerful allosteric activator of phosphofructokinase 1 (PFK-1), the enzyme that controls one of the most critical steps of glycolysis [8 - 11]. The tetrameric enzyme PFK-1 …
Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, …
2017年6月1日 · Treatment of ConA-stimulated thymocytes with PFK-2 inhibitor (3PO) or MK-2206 led to significant decreases in Fru-2,6-P 2 content, medium lactate accumulation and rates of …
Liver X Receptor α Is Involved in the Transcriptional Regulation of …
2012年4月13日 · Endogenous PFK2/FBP2 mRNA in the mouse liver was increased in the fasting/refeeding state compared with the fasting state. Altogether, PFK2/FBP2 gene …