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2024年10月9日 · 团队设计了几十种复合荧光标记，称为FRET荧光体（FRETfluor），可实现更加优异的单分子水平多重光谱测量，该技术无需清洗，可高精度鉴定生物分子靶标，对生命科学研究提供有力支持。 单分子水平的多重实时荧光检测可以揭示混合物和其他复杂样品中多种分子种类的化学计量、动力学和相互作用。 然而，由于信噪比低、光谱重叠高以及需要保持染料的化学相容性，基于荧光的传感通常仅限于一次检测3-4种颜色。 团队设计的FRETfluors突破性技术，开启 …

免疫受体酪氨酸活化基序（英語： immunoreceptor tyrosine-based activation motif ，缩写ITAM）是一个由十多个氨基酸构成的保守序列，常出现在免疫系统某些细胞的跨膜蛋白的胞内区。

By contrast, in silico, it is obtained by solving the Protein Folding problem (PFP) which currently has a long execution time. PFP is computationally an NP-hard probl...

ITAM是一种由 6-8个氨基酸残基 组成的 保守肽段，其序列为Yxx (L/I)x (6-8)Yxx (L/I)，其中 x 表示 任意 氨基酸残基，而 Y 表示 酪氨酸 残基。 ITAM 通常存 在 于 B 细胞受体、 T 细胞受体、 巨噬 细胞受体和 天然杀伤 细胞受体等 免疫细胞受体 上。 当ITAM受体结合到它们的配体时，ITAM的酪氨酸残基会被特定 酪氨酸激酶 酪氨酸激酶（tyrosine kinases）磷酸化，导致多种信号转导通路的激活，如蛋白 激酶C 、蛋白 激酶D 、蛋白 激酶A 和蛋白 激酶B 的激活。 这些通路进而引导 …

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