PFS-2 vs. PFS，晚期肿瘤临床研究的替代研究终点应如何选择？|治疗|pfs…
2024年2月22日 · 研究表明，pfs-2与os获益的相关性比pfs更强。 与PFS相比，当PFS-2作为晚期癌症研究的主要终点时，仅需额外增加中位4.3个月和12.7%的PY随访，即可验证其统计学显著 …
Validity and Efficiency of Progression-Free Survival-2 as a …
Progression-free survival (PFS)-2, defined as the time from randomization to progression on second-line therapy, is potentially a more reliable surrogate than PFS for overall survival (OS), …
The validity of progression-free survival 2 as a surrogate ... - PubMed
2022年4月1日 · Progression-free survival 2 (PFS-2), defined as the time from randomization to progression on first subsequent therapy, has been proposed as a surrogate for OS. Using a …
OS、PFS、DFS 有什么区别？一文搞懂 6 大肿瘤临床试验终点
2016年7月8日 · 无进展生存期（progression-free survival，PFS） 定义为：从随机化开始到肿瘤发生（任何方面）进展或（因任何原因）死亡之间的时间 与 OS 相比，增加了「发生恶化」这 …
The validity of progression-free survival (PFS) 2 as a surrogate ...
2021年5月28日 · PFS-2, defined as time from randomization to progression on second-line therapy, has been proposed as a potential surrogate endpoint for OS. Using a meta-analytic …
PFS、DFS、EFS 有什么区别？ 8 大肿瘤临床试验终点全解读
2024年5月5日 · 抗肿瘤药物临床试验最常用的疗效终点有总生存期（Overall Survival, OS）、客观缓解率 （Objective Response Rate, ORR）、无进展生存期（Progression Free Survival, …
Validity and efficiency of progression-free survival (PFS)-2 as a ...
PFS-2, defined as time from randomization to progression on second line therapy, is potentially a more reliable surrogate than PFS but requires additional follow-up time. We evaluated the …
CROWN研究5年PFS2数据揭晓，“3+X”模式再添新证 - 网易
2024年8月22日 · 相较于pfs，pfs2为评估治疗方案的综合效益提供了更多依据，能够在揭示一线治疗方案对患者长期生存影响的同时，反映出后续治疗的有效性和耐受性。 也有研究表明， …
Updated KRYSTAL-7 Data Show PFS Beyond 27 Months for …
4 小时之前 · In first-line treatment, the combination showed a median progression-free survival (PFS) of 27.7 months (95% CI, 8.1-NE) with a manageable safety profile, according to the …
Comparison of the efficacy and safety of docetaxel plus …
2025年3月7日 · The inclusion criteria for study selection were: (1) patients with HER2-negative breast cancer; (2) studies comparing the outcomes of TX and TE in the treatment of breast …
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