Mitochondrion-related cardiotoxicity due to cardiotoxin stimuli is closely linked to abnormal activities of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), followed by co-inactivation of nuclear respiratory factor-1(NRF1).

2022年8月5日 · NRF-1 transcription can be enhanced by binding to PGC-1α (Dangsheng, 2005); a transcription factor capable of synergizing with other transcription factors to regulate gene expression as well as other cellular physiological and metabolic reactions, such as mitochondrial biogenesis, apoptosis, and cell-fate determination (Chen et al., 2011, Cheng ...

Increased expression or activity of the key regulator of mitochondrial biogenesis PGC-1α activates the expression of NRF-1/2, which induces the expression of TFAM, which translocates to mitochondria, binds to mtDNA, and activates transcription and replication. An increase in OXPHOS proteins reduces ROS generation in mitochondria.

2008年5月2日 · In addition, PGC-1α orchestrates a program of mitochondrial biogenesis in part by serving as a trans -activator of NRF-1 and NRF-2 target genes (18). The coactivator binds NRF-1 in a manner similar to that observed for PPARγ and directs expression of respiratory subunits as well as mtDNA transcription and replication factors (18, 19).

2007年5月15日 · Early studies of PGC-1α demonstrated that it activates mitochondrial biogenesis by activating the nuclear respiratory factor 1 (NRF-1). 56 Subsequent studies revealed that this mechanism also is relevant in heart. 51 NRF-1 is a nuclear-encoded transcription factor that is coactivated by PGC-1α to regulate transcription of genes involved in ...

2007年1月17日 · Accumulating evidence supports a major role for NRF-1 in mediating the effects of PGC-1α on mitochondrial biogenesis. PGC-1α can interact specifically with NRF-1 through the NRF- 1 DNA...

The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) coactivator-1 beta (PGC-1 beta) is a well-established regulator of the beta-oxidation of fatty acids and the oxidative phosphorylation in mitochondria. However, the underlying mechanism of PGC-1 beta action remains elusive.

随着心功能分级 (NYHAⅠ～Ⅱ级、Ⅲ级和Ⅳ级)逐渐升高,CHF组患者血清TFAM、PGC-1α、NRF-1水平逐渐降低 (P<0.05);LVEDD、LVESD水平逐渐升高,LVEF水平逐渐降低 (P<0.05)。 相关性分析显示,LVEF与血清TFAM、PGC-1α、NRF-1水平呈正相关 (r=0.474、r=0.461、r=0.513,P<0.05);LVEDD与血清TFAM、PGC-1α、NRF-1水平呈负相关 (r=-0.511、r=-0.502、r=-0.475,P<0.05);LVESD与血清TFAM、PGC-1α、NRF-1水平呈负相关 (r=-0.497、r=-0.515 …

PGC-1-related coactivator (PRC) was initially characterized as a transcriptional coactivator that shares structural and functional features with PGC-1α. Both coactivators interact with nuclear respiratory factor 1 (NRF-1) and activate NRF-1 target genes required for …

2023年5月10日 · The process is initiated when PGC-1α is activated by phosphorylation of AMPK or deacetylation of SIRT1 and stimulates various nuclear transcription factors, such as NRF-1, NRF-2, and estrogen-related receptor alpha (ERRα). Through activation of NRF-1/2 , PGC-1α promotes TFAM transcription and expression [81,82].