PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A
Mitochondrion-related cardiotoxicity due to cardiotoxin stimuli is closely linked to abnormal activities of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), …
Effects of NRF-1 and PGC-1α cooperation on HIF-1α and
2022年8月5日 · NRF-1 transcription can be enhanced by binding to PGC-1α (Dangsheng, 2005); a transcription factor capable of synergizing with other transcription factors to regulate gene …
PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS …
Increased expression or activity of the key regulator of mitochondrial biogenesis PGC-1α activates the expression of NRF-1/2, which induces the expression of TFAM, which translocates to …
PGC-1-related Coactivator Complexes with HCF-1 and NRF
2008年5月2日 · In addition, PGC-1α orchestrates a program of mitochondrial biogenesis in part by serving as a trans -activator of NRF-1 and NRF-2 target genes (18). The coactivator binds …
Peroxisome Proliferator–Activated Receptor γ Coactivator-1 (PGC-1 ...
2007年5月15日 · Early studies of PGC-1α demonstrated that it activates mitochondrial biogenesis by activating the nuclear respiratory factor 1 (NRF-1). 56 Subsequent studies revealed that …
2007年1月17日 · Accumulating evidence supports a major role for NRF-1 in mediating the effects of PGC-1α on mitochondrial biogenesis. PGC-1α can interact specifically with NRF-1 through …
PGC-1 beta-regulated mitochondrial biogenesis and function in …
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) coactivator-1 beta (PGC-1 beta) is a well-established regulator of the beta-oxidation of fatty acids and the oxidative …
慢性心力衰竭患者血清TFAM、PGC-1α、NRF-1水平与心功能的相 …
随着心功能分级 (NYHAⅠ～Ⅱ级、Ⅲ级和Ⅳ级)逐渐升高,CHF组患者血清TFAM、PGC-1α、NRF-1水平逐渐降低 (P<0.05);LVEDD、LVESD水平逐渐升高,LVEF水平逐渐降低 (P<0.05)。 相关 …
PGC-1-Related Coactivator: Immediate Early Expression and ...
PGC-1-related coactivator (PRC) was initially characterized as a transcriptional coactivator that shares structural and functional features with PGC-1α. Both coactivators interact with nuclear …
PGC-1α Is a Master Regulator of Mitochondrial Lifecycle
2023年5月10日 · The process is initiated when PGC-1α is activated by phosphorylation of AMPK or deacetylation of SIRT1 and stimulates various nuclear transcription factors, such as NRF-1, …