PGC-1α is a gene that contains two promoters, and has 4 alternative splicings. PGC-1α is a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis.

Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. It is strongly induced by cold exposure, linking this environmental stimulus to adaptive thermoge …

PGC1 alpha（过氧化物酶体增殖物激活受体γ共激活剂1-alpha）是类固醇受体和核受体的转录共激活剂。 PGC1 alpha增加解偶联蛋白启动子上PPARG和甲状腺激素受体的转录活性。

过氧化物酶体增殖物激活受体γ 共激活因子-1α (peroxisome proliferator activated receptor γ coactivator-1α, PGC-1α)作为能量代谢的关键调控因子,已成为当前研究的热点。 它能够灵敏应答于各种环境刺激和营养信号的改变,并通过选择性地结合不同转录因子,协同控制包括葡萄糖稳态、脂质代谢平衡和生物时钟稳态在内的多种生理进程。 本文回顾了PGC-1α基因和蛋白的结构,深度阐明了PGC-1α在肝脏、骨骼肌以及心脏等哺乳动物重要能量代谢器官中的组织特异性代谢调节功 …

2024年3月1日 · Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related...

2020年3月9日 · Peroxisome proliferator-activated receptor- γ coactivator (PGC)-1 α is a transcriptional coactivator described as a master regulator of mitochondrial biogenesis and function, including oxidative phosphorylation and reactive oxygen species detoxification. PGC-1 α is highly expressed …

Mitochondrial transcription is activated by PGC-1α, PGC-1β, and PRC, but PGC-1α is the master regulator of mitochondrial biogenesis. The process is initiated when PGC-1α is activated by phosphorylation of AMPK or deacetylation of SIRT1 and stimulates various nuclear transcription factors, such as NRF-1, NRF-2, and estrogen-related receptor ...

2023年9月7日 · The peroxisome proliferator-activated receptor gamma (PPARγ) coactivator 1 alpha (PGC-1α, encoded by the PPARGC1A gene) exerts a central regulatory role in sensing...

PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, including components of the electron transport system. PGC-1α is expressed abundantly in tissues with high energy demand, including brown adipose tissue, heart, skeletal muscle, kidney, and brain.

PGC-1α is a molecular switch that induces key adaptive thermogenic program components in brown fat, which involves the activation of mitochondrial fatty-acid oxidation, fuel intake, and heat production by uncoupling protein-1 (UCP1) expression .