2019年11月21日 · In our study, we observed that the ratio of BCL2 to BAX mRNA expression levels was higher after systemic aPGF 2α treatment compared to its local injection in the early-stage CL. In contrast, in the middle-stage CL this ratio of mRNA expression was markedly decreased after systemic PGF 2α injection compared to its local administration.

促凋亡基因代表成员 Bax，能够编码 α、β、γ、δ、ε、σ 共 6 种 Bax 蛋白亚型。 Bax 基因编码的具有生物学活性的 Baxα （21 kD），是 Bax 基因在细胞中发挥促凋亡作用的主要表达形式。

2019年11月21日 · In our study, we determined changes in expression of genes related to: (i) apoptosis: caspase (CASP) 3, CASP8, BCL2 associated X (BAX), B-cell lymphoma 2 (BCL2) and (ii) necroptosis: receptor-interacting protein kinase (RIPK) 1, RIPK3, cylindromatosis (CYLD), and mixed lineage kinase domain-like (MLKL) in the early and mid-stage corpus luteum ...

2018年10月1日 · TGF decreases luteal cells viability and through BAX and FASL expression and caspase 3 activity. ALK5, ALK4 and ALK7 are important mediators of PGF2alpha luteolytic actions. In the present report we describe the involvement of transforming growth factor B1 (TGF) in functional regression and structural luteolysis in the mare.

Cell cycle distribution, Caspase-3 enzyme activity, Bad and Bax protein expression through flow cytometry and molecular docking were carried out to analyze the NK1 receptor activity. Results: We found that PGF2a has a high binding affinity towards NK1 …

Download scientific diagram | Effect of PGF2a on expression of Bax, Bcl-2 and Akt genes during PGF2a treatment. (A) qPCR expression and analysis of Bax and Bcl-2 in the bovine CL. Mean (6SEM) fold ...

2018年6月1日 · Molecular regulation in the mature canine CL following multiple low-doses PGF2 α is investigated. We have carefully monitored luteal gene expression during the different stages of luteolysis. This regimen caused an apparent decline in P 4 levels and changes in gene expression in luteal tissue.

Our group’s previous research indicated that prostaglandin F2α (PGF2α) acts as an eicosanoidal protector against non-proliferative DR that can regulate the mobility of pericytes in a RhoA-mediated manner. However, the effect of PGF2α on pericyte apoptosis has yet to be described.

The model also shows involvement of Bcl-2 family members, Bax (pro-apoptotic) and Bcl-2 (anti-apoptotic) that cause changes in mitochondrial permeability to apoptogenic molecules.

The relative abundance of mRNA transcripts for candidate genes was quantified: BCL-2associated X protein (BAX) (Zhao et al., 2014), B-cell lymphoma 2 (BCL2), platelet endothelial cell adhesion ...