We investigated the metabolic control of cardiac glycolysis and explored the potential of glucose 6-phosphate (G6P) to regulate glycolytic flux and mTOR activation. We developed a kinetic model of cardiomyocyte carbohydrate metabolism, CardioGlyco, to study the metabolic control of myocardial glycolysis and G6P levels.

Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme ( EC 5.3.1.9) that in humans is encoded by the GPI gene on chromosome 19. [4] This gene encodes a member of the glucose phosphate isomerase protein family.

2020年12月9日 · Phosphoglucoisomerase (PGI) isomerizes fructose 6-phosphate (F6P) and glucose 6-phosphate (G6P) in starch and sucrose biosynthesis. Both plastidic and cytosolic isoforms are found in plant leaves. Using recombinant enzymes and isolated chloroplasts, we have characterized the plastidic and cytosolic isoforms of PGI.

6-磷酸葡萄糖酸酯酶（英文缩写为pgi）是一种重要的酶，它参与碳水化合物代谢途径中的关键步骤。 它主要负责将6-磷酸葡萄糖酸（G6P）转化为6-磷酸果糖酸（F6P），通过催化反应将一个磷酸基从G6P的第6位转移至F6P的第1位。

2017年12月1日 · Glucose 6-phosphate isomerase (Pgi), locates at the branching point of catabolism and anabolism pathways and reversibly converts the intermediate glucose 6-phosphate to fructose 6-phosphate, which is essential for the upstream glycolysis and gluconeogenesis pathways.

2024年3月16日 · 英文：glucose-6-phosphate isomerase; 催化反应：D-葡萄糖-6-磷酸⇔D-果糖-6-磷酸; 系统名称：D-葡萄糖-6-磷酸 醛糖-酮糖-异构酶. 英文： D-glucose-6-phosphate aldose-ketose-isomerase; CAS号：9001-41-6; 注释：也催化D-葡萄糖-6-磷酸的端基异构体。

2019年11月8日 · Metabolic control analysis revealed that G6P concentration is dependent on phosphoglucose isomerase (PGI) activity. Next, we integrated ex vivo tracer studies with mathematical simulations to...

Metabolic control analysis revealed that G6P concentration is dependent on phosphoglucose isomerase (PGI) activity. Next, we integrated ex vivo tracer studies with mathematical simulations to test how changes in glucose supply and glycolytic flux affect mTOR activation.

2018年12月1日 · PGI catalyzes the conversion of F6P into G6P, which then is oxidized into 6-phosphogluconolactone (6PGL) by the NADP-dependent G6PDH. Finally, NADPH is used to reduce resazurin into resorufin, and the fluorescence intensity signal is detected using a microplate reader.

2019年11月8日 · We demonstrate that PGI inhibition promotes glucose 6-phosphate accumulation and supports protein synthesis in cardiomyocytes. Mathematical modeling shows that PGI inhibition decreases glycolytic flux and redirects glucose 6-phosphate into the pentose phosphate pathway.