蛋白基因产物9.5(Protein gene product 9.5,PGP 9.5),是一种神经纤维中的特异性泛素羟基水解酶,作为一种神经轴突标记物,抗PGP9.5抗体可以与任何无髓或有髓的神经纤维相结合,使用免疫荧光或免疫组织化学的方法即可标记出组织中PGP 9.5阳性的神经纤维.目前在国外,PGP 9.5 ...

2003年10月1日 · In non-neoplastic tissues, the expression of protein gene product 9.5 (PGP 9.5), a member of the ubiquitin hydrolase family of proteins, is confined to neural and neuroendocrine cells.

Protein gene product 9.5 (PGP 9.5) is deubiquitinating enzyme expressed mostly in neurons and neuroendocrine cells, and it is used as a biomarker to identify peripheral nervous system axons. 8 It has been detected that approximately 80% of ureter nervous fibers contain PGP 9.5. 9 Lack of PGP 9.5 expression can be associated with axonal atrophy. 10

UCHL1/PGP 9.5 (also known as UCHL1 and PGP 9.5) was first detected as a "brain-specific protein" over 28 years ago. The protein is highly conserved and localized in neurones and neuroendocrine cells in vertebrates, forming an estimated 5-10% of cytoplasmic protein.

2003年10月1日 · In non-neoplastic tissues, the expression of protein gene product 9.5 (PGP 9.5), a member of the ubiquitin hydrolase family of proteins, is confined to neural and neuroendocrine cells.

PGP 9.5 is a ubiquitin-carboxyl hydrolase that is expressed in nerve tissues from mice brains at all stages of differentiation, 1-6 and thus it has been regarded as an universal cytoplasmic marker for neuroendocrine cells and neuroendocrine tumors (NETs) since the 1980s. 1-6 However, PGP 9.5 has not gained popularity as a diagnostic and ...

In non-neoplastic tissues, the expression of protein gene product 9.5 (PGP 9.5), a member of the ubiquitin hydrolase family of proteins, is confined to neural and neuroendocrine cells. Although it has been claimed that PGP 9.5 is a specific marker …

Purification of bovine PGP 9.5 confirmed that it is also a ubiquitin carboxyl-terminal hydrolase. These results suggest that a family of such related proteins exists and that their expression is tissue-specific.

1983年11月14日 · PGP 9.5 is a new cytoplasmic neuron-specific protein structurally and immunologically distinct from neuron-specific enolase. A specific antiserum has now shown that this protein is widely distributed in vertebrate brains and is also present in cells of the human diffuse neuroendocrine system.

蛋白基因产物9.5(protein gene product 9.5,PGP 9.5)存在于所有传入和传出神经纤维中,是一个非常好的泛神经标记物,对神经纤维特异性强。 作为一种神经轴突标记物,抗PGP 9.5抗体可以与任何无髓或有髓的神经纤维相结合。