2019年12月9日 · OPA1 cleavage is regulated by the prohibitin (PHB) complex, a heteromeric, ring-shaped mitochondrial inner membrane scaffolding complex composed of PHB1 and PHB2. In neurons, PHB plays a...

The localization of M1 and M2 BV2 markers was detected using immunofluorescence analysis. The results showed that lobetyolin could protect BV2 cells from OGD/R-induced damage. After OGD/R, CKLF1/C-C chemokine receptor type 4 (CCR4) levels increased in BV2 cells, whereas the CKLF1/CCR4 level was decreased due to lobetyolin pretreatment.

2021年6月2日 · In the mitochondria, PHB2 associates with the homologous protein PHB1, forming a large oligomeric ring-like structure in the inner mitochondrial membrane 10. This structure is thought to act as a...

2012年1月1日 · We have demonstrated that PHB is upregulated in PC induced by FN stimulation or cerebral ischemia in vivo, and by OGD in vitro. PHB is present in neuronal mitochondria and its expression increases the resistance of neuronal cultures to STS or oxidative stress, and hippocampal slices to OGD.

2020年4月15日 · Here, we test this hypothesis using oxygen and glucose deprivation (OGD), an in vitro neuronal model of ischemic stress. We show that NO and PHB are mutually required to maintain cell viability in hypoxic stress, and that mechanistically NO directly interacts with PHB, resulting in PHB protein S-nitrosylation in its sole Cys residue.

2024年12月25日 · PHB1 (Prohibitin 1) is a Protein Coding gene. Diseases associated with PHB1 include Breast Cancer and Chikungunya. Among its related pathways are Signaling downstream of RAS mutants and MAPK family signaling cascades. An important paralog of this gene is PHB2.

phb1是一类具有多种功能并且与多种疾病相关的蛋白，然而目前还没任何一种针对phb1的抑制剂或拮抗剂产生，从而导致对phb1的研究进展缓慢。 在这个基础上，从一个五个氨基酸组成的五肽库（205=三百二十万个）中筛选出了一种可以与PHB1结合的小肽分子Pep5。

目的观察自噬对氧糖剥夺复氧（ogd/r）后大脑皮层神经元凋亡的影响。方法选择24小时内出生的新生sd大鼠18只。通过机械胰蛋白酶消化提取皮质神经元并培养7天。建立ogd/r模型。将大鼠随机分为3组：对照组、ogd/r组、ogd/r联合巴弗洛霉素a1(bafa1)组。

2025年1月1日 · Using recombinant PHB1 proteoliposomes reconstituted into MIM-mimicking phospholipids, we found that PHB1 forms an oligomer via its carboxy-terminal coiled-coil region. A proline substitution into the PHB1 coiled-coil collapsed its well-ordered oligomeric state, and its destabilization correlated with mitochondrial morphologic defects.

Cleavage of functional long OPA1 (L-OPA1) isoforms by OMA1 inactivates mitochondrial fusion and primes apoptosis. OPA1 cleavage is regulated by the prohibitin (PHB) complex, a heteromeric, ring-shaped mitochondrial inner membrane scaffolding complex …