Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus. [8] .

2024年12月25日 · PIM1 (Pim-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM1 include Myeloma, Multiple and Myeloproliferative Neoplasm. Among its related pathways are FLT3 signaling in …

The highly conserved proto-oncogenic protein PIM1 is an unusual serine or threonine kinase, in part because it is constitutively active. Overexpression of PIM1 experimentally leads to tumor formation in mice, while complete knockout of the protein has no observable phenotype.

PIM1 kinase is often overexpressed in solid and hematopoietic malignancies, promoting cell survival, proliferation, migration, and senescence by activating key genes. In vitro and in vivo studies have established the oncogenic potential of PIM1 kinases.

As PIM1 has great potential to induce cancer stem cell properties to accelerate prostate cancer progression, targeting PIM1 in cancer stem cells using selective inhibitors may provide a new avenue for treatment of aggressive prostate cancer.

2016年10月24日 · In triple-negative breast cancer, the kinase PIM1, which is highly expressed, functions through the transcription factor c-MYC to promote tumor cell survival and growth.

2024年11月1日 · PIM1 kinase is often overexpressed in solid and hematopoietic malignancies, promoting cell survival, proliferation, migration, and senescence by activating key genes. In vitro and in vivo studies have established the oncogenic potential of PIM1 kinases.

2020年5月7日 · Proviral integration site for Moloney-murine leukemia 1 (PIM1) is a known JAK-STAT target gene that recently emerged as a therapeutic target for the treatment of T-ALL and T-LBL. 2-7 PIM1 activation in primary T-ALL/T-LBLs can occur through T-cell receptor–driven translocations 5,6 or activating mutations targeting IL7RA, JAK1, JAK3, or ...

Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis (PubMed:19749799).

2021年11月5日 · Background: PIM1 is a somatic hypermutation gene in diffuse large B-cell lymphoma (DLBCL) and its inhibitors exhibit a great value in application in multiple types of lymphoma. Nevertheless, investigation on its genetic alterations, biological characteristics, clinical significance and response to drugs is still lacking.

2015年12月3日 · It is reported that Pim-1 plays a role in solid tumor, leukemia and polycythemia vera, et al. Pim-3, as a newly cloned oncogene has discovered to functioning in hepatic carcinoma, pancreatic cancer, et al. We are trying to find out the roles of Pim1 in acute myeloid leukemia. Methods:

We identify PIM1 as a malignant cell-selective target in TNBC, illustrating relationships with MYC activation, regulation of anti-apoptotic BCL2 and MCL1, established TNBC oncogenic proteins SHP2 and EPHA2 and cell cycle inhibitor p27.

Infection causes the production of the inflammatory cytokine interferon-γ (IFN-γ), which triggers the expression of hundreds of IFN-stimulated-genes, including the kinase PIM1 and GBP1, a membrane-perturbing GTPase. Fisch et al. identified a guard mechanism whereby PIM1 phosphorylates GBP1 and subjects it to sequestration by a 14-3-3 protein.

2010年6月1日 · Our results suggest an in vivo role of Pim1 in promoting prostate tumorigenesis although it displayed distinct oncogenic activities depending on the disease stage of the cell line. Pim1 promotes tumorigenicity at least in part by enhancing c-MYC transcriptional activity.

2024年12月1日 · Pim1 deficiency reduces BCR-induced cell proliferation and cell cycle progression. Pim1 deficiency impairs BCR-induced MAPK activation. The Pim family consists of three members that encode a distinct class of highly conserved serine/threonine kinases.

The proviral integration site for moloney murine leukemia virus 1 (Pim1) is a serine/threonine kinase and able to promote cell proliferation, survival and drug resistance. Overexpression of Pim1 has been observed in many cancer types and is ...

2006年12月29日 · In DLBCL somatic hypermutation aberrantly targets the 5′ sequences of several proto-oncogenes relevant to lymphomagenesis, including PIM1, PAX5, RhoH/TTF, and cMYC.

2024年7月15日 · PIM1 targets the NRF2/HO-1/NQO1 signaling pathway to resist oxidative stressors and apoptosis. PIM1 improves hepatic function, inflammation, and lipogenesis to alleviate NAFLD.

Disclosed herein, inter alia, are methods and compositions useful for serially detecting multiple biological targets.

2006年8月1日 · To assess whether the SHM process functions aberrantly in HL, we investigated tumor cells microdissected from frozen lymph node samples of NLPHL and cHL for the presence of mutations in the PIM1, PAX5, RhoH/TTF, and c-MYC genes.