PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene. [5] [6] It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria.

3 天之前 · Mutations in the protein kinase PARK6/PINK1 lead to early-onset forms of Parkinson’s Disease (EOPD) ().PINK1 is a ubiquitin and Parkin kinase (2–7) and functions as an early sensor and transducer of mitochondrial damage signaling (8–10).In healthy mitochondria, PINK1 is translocated across the mitochondrial outer membrane (MOM) via the translocase of the outer membrane (TOM) complex ...

3 天之前 · The PINK1 ubiquitin signal is unique to damaged mitochondria, and when PINK1 is mutated in patients, broken mitochondria accumulate in cells. Although PINK1 has been linked to Parkinson’s, and in particular Young Onset Parkinson’s Disease, researchers had been unable to visualise it and did not understand how it attaches to mitochondria and ...

1 天前 · The link between PINK1 and Parkinson's . One of the hallmarks of Parkinson's is the death of brain cells. Around 50 million cells die and are replaced in the human body every minute. But unlike ...

2024年12月25日 · PINK1 (PTEN Induced Kinase 1) is a Protein Coding gene. Diseases associated with PINK1 include Parkinson Disease 6, Autosomal Recessive Early-Onset and Early-Onset Parkinson's Disease. Among its related pathways are Gene expression (Transcription) and Selective autophagy.

3 天之前 · The link between PINK1 and Parkinson’s . One of the hallmarks of Parkinson’s is the death of brain cells. Around 50 million cells die and are replaced in the human body every minute. But ...

2024年10月2日 · Mitophagy mediated by the recessive Parkinson’s disease genes PINK1 and Parkin responds to mitochondrial damage to preserve mitochondrial function. In the pathway, PINK1 is the damage sensor,...

The PINK1 gene provides instructions for making a protein called PTEN induced putative kinase 1. This protein is found in cells throughout the body, with highest levels in the heart, muscles, and testes.

2010年3月16日 · PINK1 type of young-onset Parkinson disease is characterized by early onset (median age at onset 32 years) of tremor, bradykinesia, and rigidity that are often indistinguishable from other causes of Parkinson disease. Lower-limb dystonia may be …

In this chapter, we will summarize the roles of PINK1 in regulating mitochondrial function, quality control, and trafficking, as well as discuss several emerging neuron-specific functions of PINK1.