2020年6月4日 · We report that Pitx2 (the first transcriptional marker for tooth development) controls the embryonic formation and patterning of epithelial signaling centers during incisor …

2022年12月6日 · In this study, we generated a dual-fluorescence reporter knock-in mouse (Pitx2 P2A-copGFP; Msx1 P2A-tdTomato) to label and track dental cells through various …

One is ∼61 kb from PITX2, a major determinant of tooth development. Another overlaps HS3ST3A1, a paralogous neighbor of HS3ST3B1, a tooth enamel knot factor. We document …

Mechanistically, Pitx2 and Sox2 interact physically and regulate Lef-1, Pitx2 and Sox2 expression during development. Thus, we have uncovered a Pitx2-Sox2-Lef-1 transcriptional mechanism …

2023年1月6日 · Tooth number abnormality is one of the most common dental developmental diseases, which includes both tooth agenesis and supernumerary teeth. Tooth development is …

2025年1月6日 · We document the expression of Pitx2 and Hs3st3a1 in enamel knot and dental epithelial cells of developing mouse incisors. Furthermore, associated SNPs in PITX2 and …

Pitx2 is necessary for the formation of the signaling centers, and the deletion of Pitx2 in the dental epithelium results in an arrest of tooth development. Pitx2 interacts with Sox2 and Lef1 to …

2024年7月25日 · These results uncover a previously unknown molecular mechanism involving cross-repression of domain specific TFs including Pitx2 and Tfap2a/Tfap2b in patterning the …

Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration.

2022年12月6日 · In this study, we generated a dual-fluorescence reporter knock-in mouse (Pitx2 P2A-copGFP; Msx1 P2A-tdTomato) to label and track dental cells through various …