What is Peutz-Jeghers syndrome (PJS)? Peutz-Jeghers syndrome (PJS) is a condition that causes polyps to form inside your body and dark-colored spots to appear on your face, hands, feet and elsewhere. Both the polyps and the spots are benign (noncancerous). Still, having PJS substantially increases your cancer risk.

2008年7月18日 · Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by melanotic macules, intestinal polyps, and an increased cancer risk. It is caused by mutations in the serine/threonine kinase 11 gene (LKB1, STK11).

2023年7月17日 · Peutz-Jeghers syndrome is an autosomal dominant inherited disorder. It is most often due to germ-line mutations in the STK11 (LKB1) on chromosome 19p13.3. STK11 is a tumor suppressor gene that regulates cell polarity. The gene encodes serine/threonine kinase 11, which plays an important role in regulating the cell cycle.

Peutz-Jeghers syndrome is characterized by the development of noncancerous growths called hamartomatous polyps in the gastrointestinal tract (particularly the stomach and intestines) and a greatly increased risk of developing certain types of cancer.

Peutz–Jeghers syndrome (often abbreviated PJS) is an autosomal dominant genetic disorder characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa (melanosis). [2] .

Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. The PJ gene was recently mapped to chromosome 19p13.3 by link …

Peutz-Jeghers syndrome (PJS) is a rare genetic disorder characterized by the development of gastrointestinal polyps, mucocutaneous pigmentation, and an increased risk of various types of cancer [1].

Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk...

1998年9月1日 · Peutz–Jeghers (PJ) syndrome is an autosomal-dominant inherited disorder characterized by melanocytic macules on the lips, perioral regions, and mucous membranes; multiple gastrointestinal polyps; and an increased risk of benign and malignant neoplasms of the intestinal tract and other organs.

Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.