2022年10月18日 · MAPK (ERK) pathway activation was common to both intrinsic and acquired resistance cellular models. The overexpression of upstream RAS/RAF, however, was confined to JIMT 1; meanwhile, in a cellular model of acquired trastuzumab resistance generated in this study (T15), entry into the ERK pathway seemed to be mostly mediated by PKCα activation.

In the absence of RAF overexpression, entry into the MEK/ERK pathway can be mediated by the protein kinase C (PKC) family, via PDK1. PKCα and PKCγ are both members of the diacylglycerol (DAG) sensitive, Ca 2+ responsive conventional PKC (cPKC) isoform subgroup.

2022年10月17日 · MAPK (ERK) pathway activation was common to both intrinsic and acquired resistance cellular models. The overexpression of upstream RAS/RAF, however, was confined to JIMT 1; meanwhile, in a cellular model of acquired trastuzumab resistance generated in this study (T15), entry into the ERK pathway seemed to be mostly mediated by PKCα activation.

2013年1月5日 · At the intracellular level, euphol reduced TPA-induced extracellular signal-regulated protein kinase (ERK) activation and cyclooxygenase-2 (COX-2) upregulation. These effects were associated with euphol's ability to prevent TPA-induced protein kinase C (PKC) activation, namely PKCα and PKCδ isozymes.

2013年8月1日 · PKC-dependent ERK phosphorylation is essential for P2X 7 receptor-mediated neuronal differentiation of neural progenitor cells. H-K Tsao 1, P-H Chiu 1 & S H Sun 1

1996年9月20日 · A Raf-dependent intact cell assay system for monitoring the activation of MAPK/ERK kinase (MEK) and extracellular signal-related kinase (ERK) permitted us to evaluate the role of PKC isotypes in MAP kinase activation. Treatment of cells with TPA or epidermal growth factor resulted in the activation of MEK and ERK.

2001年11月16日 · Different PKC isoforms activate pools of ERKs in distinct subcellular localizations. PKC ε activates ERK at focal adhesions, while PKC α activates nuclear ERK.

2010年12月2日 · ERK通路 的激活包括了以下3种方式：酪氨酸激酶受体对Ras的激活、Ca2+对Ras的激活以及PKC对ERK通路的激活。生长因子与细胞表面的受体酪氨酸激酶(RTK)结合，诱发生长因子受体胞质中的酪氨酸残基自身磷酸化，导致受体二聚体化与活化。

2025年1月1日 · Glioblastoma multiforme was sensitive for elimination by apoptosis upon sorafenib and TMZ application after siPLCγ1 transfection (over 60%). It brings the conclusive proof for Ras/Raf/MEK/ERK, and PLCγ1/PKC pathways regulated by TrkB receptor engagement in the resistance of glioma cells upon Temozolomide treatment.

2005年5月15日 · PKC stimulation activates ERK through different pathways depending on the cell types, both Ras-dependent and Ras-independent mechanisms are involved. In GN4 rat liver epithelial cells, AngII activated ERK via a PKC-dependent, Ras-independent pathway [11].