ROS Production via P2Y1-PKC-NOX2 Is Triggered by Extracellular …
2015年6月8日 · Our results indicate that physiological levels of electrical stimulation induce ROS production in skeletal muscle cells through release of extracellular ATP and activation of P2Y1 …
Unlocking the power of NOX2: A comprehensive review on its role …
The relay of signals from the TCR to mitochondria involves activation of the Protein kinase C (PKC) ϑ which translocates to mitochondria upon TCR engagement and induces sROS …
Nox family NADPH oxidases: Molecular mechanisms of activation
2014年11月1日 · In skeletal muscle cells, insulin induces an increase in H 2 O 2 through a PKC-dependent pathway which was blocked by a Nox2-inhibitory peptide as well as by p47phox …
NADPH oxidase 2 (NOX2): A key target of oxidative stress ... - PubMed
NOX2 is an isoform from NADPH oxidase expressed in platelets and an important regulator of platelet activation-associated thrombosis. The present article aims to highlight the relative …
Cell Signaling through Protein Kinase C Oxidation and Activation
In human monocytes and murine macrophages PI3K and PKC pathways are involved in Nox2 stimulation in response to insulin. This mechanism triggers ERK1/2, p38MAPK and NFκB, …
基于PKC-Nox-ROS途径的运动性疲劳机制研究 - 百度学术
研究目的:骨骼肌中NADPH氧化酶(Nox)具有促使活性氧(ROS)生成的作用,它在骨骼肌中存在不同Nox分型.近十余年的研究表明,Nox是运动诱导骨骼肌ROS增加的主要途径.然而,运动性Nox的 …
ROS Production via P2Y1-PKC-NOX2 Is Triggered by Extracellular …
2015年6月8日 · In this work, we describe a novel mechanism for ROS production via PKC-NOX2 activation induced by extracellular ATP released from adult cultured muscle cells after …
PKCδ-Mediated Nox2 Activation Promotes Fluid-Phase
2018年3月26日 · PKCδ/Nox2-mediated antigen macropinocytosis stimulates maturation of DCs and secretion of T-cell stimulatory cytokines. These findings may contribute to a better …
Peroxide generation by p47phox-Src activation of Nox2 has a key …
2009年1月23日 · Peroxide-derived from Nox2 activation by PKC appeared to be a major contributor to the thromboxane A 2 receptor agonist U46619 (100 nM)-elicited contraction of …
Oxidative stress induced by NOX2 contributes to neuropathic pain …
2021年5月6日 · Although the activation and plasma membrane translocation of protein kinase C (PKC) isoforms in dorsal root ganglion (DRG) neurons have been implicated in multiple pain …