2019年5月28日 · pkm1和pkm2的表达有很大差异：pkm1主要在肌肉和脑这些对能量需求旺盛的分化终末细胞中表达，而pkm2则主要在胚胎细胞、干细胞和肿瘤细胞这些对合成代谢需求强的细胞中表达。

PKM1主要在终末分化的非增殖细胞中表达，与PKM2相比，与PKM1相关的研究相对较少。 与PKM2可以在四聚体和二聚体之间进行转换不同，PKM1不存在二聚体形式，不具备基因表达调控功能，因此只在心脏、大脑和肌肉等需要大量能量供应的组织中高表达 [11]。 研究表明，心肌细胞特异性Pkm1敲除会导致心肌细胞的生长缺陷并加剧心脏功能障碍和纤维化，从而对压力过载产生反应 [12]。 在某些肿瘤中， PKM1发挥着和PKM2相反的作用，PKM1的敲除会导致PKM2表达 …

2021年8月31日 · Inducible overexpression of PKM1 in cardiomyocytes protects the heart against transverse aortic constriction-induced cardiomyopathy and heart failure. At the mechanistic level, PKM1 is required for the augmentation of glycolytic flux, mitochondrial respiration, and ATP production under pressure overload.

2022年5月24日 · We demonstrate that PKM1 suppresses glycolysis and inhibits hypoxia-inducible factor-1 alpha. These data suggest that reduced PKM1 is, in part, responsible for increased glycolysis and...

pkm1是糖酵解反应中的重要限速酶之一，通过调节糖酵解途径，在多种癌症中发挥作用，包括结直肠癌及肺腺癌等。有研究 显示，敲低pkm1促进了结直肠癌细胞的增殖，并上调了与dna复制和细胞周期过渡相关的细胞周期调节因子的表达。

To this end, normal human fibroblasts were genetically-engineered to express the two isoforms of pyruvate kinase M (PKM1 and PKM2), a key enzyme in the glycolytic pathway. In a xenograft model, fibroblasts expressing PKM1 or PKM2 greatly promoted the growth of co-injected MDA-MB-231 breast cancer cells, without an increase in tumor angiogenesis.

We show that PKM1, rather than PKM2, exhibits tumor-promoting function cell autonomously in a Kras G12D mouse model and in KRAS G12V mouse embryo fibroblasts, and that pulmonary NETs, including SCLC, express PKM1 required for cell proliferation in that context. These findings challenge the idea that limiting glucose catabolism by PKM2 is a ...

2024年9月20日 · SCLC is characterized by highly active glycolytic metabolism and pyruvate kinase M1 (PKM1) is one of the isozymes of PK, an important rate-limiting enzyme in glycolysis pathway. Previous studies have shown that PKM1 is related to autophagy and drug sensitivity, however, how PKM1 regulates drug sensitivity in SCLC and its mechanism remain unclear.

2015年7月1日 · Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There are four mammalian pyruvate kinase isoforms with unique tissue expression patterns and regulatory properties.

m1, pkm1）是糖酵解途径中重要的限速酶pk的同工酶之一。研究表明pkm1与自噬及药物敏感性有关，但pkm1 如何调控 sclc药物敏感性及其作用机制尚不清楚。本研究旨在探讨pkm1在 中的生物学功能，包括pkm1对