Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species
We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibition of the glycolytic enzyme pyruvate kinase M2 (PKM2) through oxidation of …
The role of PKM2 in cancer progression and its structural and ...
2024年2月8日 · When the intracellular ROS concentration increases, the cysteine at position 358 of PKM2 will be oxidized and the activity of PKM2 will be reduced. This causes glucose to be …
Pyruvate kinase M2 activators promote tetramer formation and …
Low PKM2 activity, in conjunction with increased glucose uptake, facilitates the flux of glucose carbons into anabolic pathways derived from glycolysis 3,9,17,18. Also, PKM2, but not PKM1, …
PKM2 and cancer: The function of PKM2 beyond glycolysis
Oxidation of PKM2 at cysteine-358 confers an advantage to cancer cells, as it allows the cells to withstand ROS . Intracellular ROS-induced oxidation of cysteine-358 decreases the activity of …
Mitochondrial PKM2 regulates oxidative stress-induced apoptosis …
2016年12月30日 · Increased intracellular ROS level causes inhibition of glycolytic activity of PKM2 through oxidation of cysteine 358, which diverts glucose flux into the pentose …
Pyruvate kinase M2: A simple molecule with complex functions
2019年11月1日 · EGFR/ERK2-dependent PKM2 phosphorylation or oxidation of the sulfhydryl group of cysteine-358 (C-358) inhibited PKM2, and it was proposed to promote PKM2 nuclear …
the glycolytic enzyme pyruvate kinase M2 (PKM2) through oxidation of Cys358. This inhibition of PKM2 is required to divert glucose flux into the pentose phosphate pathway and thereby …
Emerging roles of PKM2 in cell metabolism and cancer progression
2012年11月1日 · Structural and biochemical analyses demonstrated that cysteine 358 in PKM2 was oxidized in cells treated with diamide (Table 1). Cysteine oxidation impaired PKM2 …
Inhibition of pyruvate kinase M2 by reactive oxygen species …
We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibition of the glycolytic enzyme pyruvate kinase M2 (PKM2) through oxidation of …
Regulation and function of pyruvate kinase M2 in cancer
2013年10月10日 · Acute increases in intracellular ROS inhibit PKM2 activity through oxidation of PKM2 cysteine 358, which diverts glucose flux to the pentose phosphate pathway and thus …