Pyruvate kinase M2 activation reprograms mitochondria in ... - Cell …
2025年4月7日 · In this report, Mortazavi Farsani et al. establish the roles of activated PKM2 in CD8 lymphocytes. Guided by multi-omics analyses, the authors show that PKM2 activation …
PKM2-G-quadruplex interactions conspire to regulate the ... - Cell …
2024年10月3日 · In this issue of Molecular Cell, Anastasakis et al. describe a novel function of the metabolic enzyme PKM2 as an RNA G-quadruplex binding protein, which could contribute to …
PKM2 is a key factor to regulate neurogenesis and ... - Cell Press
2025年1月14日 · Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme in glycolysis, is highly expressed in neural stem/progenitor cells. This enzyme is critical for adult hippocampal …
The role of PKM2 in cancer progression and its structural and ...
2024年2月8日 · In studies on non-small cell lung cancer (NSCLC), hypoxia-induced exosomal secretion of PKM2 has been found to metabolically reprogram cancer-associated fibroblasts …
PKM2-mediated metabolic reprogramming of microglia in
2025年4月6日 · We explore the regulatory mechanisms governing PKM2 activity, its influence on microglial activation and immune responses, and its contribution to the progression of various …
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T …
2025年4月7日 · Metabolic reprogramming influences the differentiation and function of T cell subsets, exerting a profound impact on immune responses. 4, 28, 53 PKM2 exerts …
Pyruvate kinase M2 at a glance | Journal of Cell Science | The …
2015年5月1日 · In this Cell Science at a glance article and accompanying poster, we provide a brief overview of recent advances in understanding the mechanisms underlying the regulation …
Metabolic Reprogramming Into a Glycolysis Phenotype Induced by ...
2025年3月13日 · Prostate cancer cell PC-3AcT was resistant to cellular death in an acidic medium. ... transition of recipient cells could be stimulated by cargo transfer of EVs including …
PKM2, a Central Point of Regulation in Cancer Metabolism
2013年2月14日 · The M2 isoform of pyruvate kinase (PKM2) catalyzes the final and also a rate-limiting reaction in the glycolytic pathway. In the PK family, PKM2 is subjected to a complex …
Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac ...
2020年2月11日 · We investigated the effect of Pkm2 in cardiomyocytes through models of loss (cardiomyocyte-specific Pkm2 deletion during cardiac development) or gain using …