Viral sensing by epithelial cells involves PKR- and caspase-3 …
2023年9月15日 · Here, we show that poly (I:C), a mimic of viral dsRNA, is sensed by NLRP1 in human bronchial epithelial cells, leading to inflammasome-dependent gasdermin D (GSDMD) …
PKR deficiency delays vascular aging via inhibiting GSDMD …
2023年1月20日 · These results demonstrate that endothelial PKR activation induces GSDMD-mediated endothelial cell hyperactivation to release HMGB1 and IL-1β, which promotes the …
PKR activation induces GSDMD-mediated endothelial cell hyperactivation to release HMGB1 and IL-1b, which promotes the phenotype transforming of VSMC and subsequent accelerates the …
Chicken GSDME, a major pore-forming molecule responsible for …
2024年11月22日 · Recent evidences reveal that GSDME, also called DFNA5, can be cleaved by caspase-3 or Granzyme B to induce pyroptosis (4, 5, 7). The cleavage of GSDME can switch …
细胞焦亡&GSDM家族：GSDMD - 知乎 - 知乎专栏
GSDM家族的所有成员（DFNB59除外）包含一个细胞毒性N末端结构域和一个由灵活接头连接的C末端阻遏物结构域，对两个结构域之间的蛋白切割位点可由半胱天冬酶（Caspase）酶切加 …
Nature Communications丨Gasdermin E 通过控制中性粒细胞的死 …
GSDME 在中性粒细胞死亡过程中通过 PR3 /caspase-3 轴被裂解. 先前的研究表明，GSDME 被凋亡的 caspase-3 激活，驱动肿瘤细胞焦亡和抗肿瘤免疫。Chen 等人证实，外源性和内源性凋 …
Gasdermin-E (GSDME)靶点介绍及实验小贴士| Abcam中文官网
Gasdermin-E (GSDME)靶点介绍助您了解其蛋白功能，蛋白定位，蛋白表达及异构体和翻译后修饰。 同时列举了实用的WB实验小贴士，助您实验成功。 Gasdermin-E (GSDME)靶点介绍及 …
Zika virus causes placental pyroptosis and associated adverse fetal ...
2022年8月16日 · Here, we demonstrated that ZIKV causes the pyroptosis of placental cells by activating the executor gasdermin E (GSDME) in vitro and in vivo. Mechanistically, TNF-α …
Gasdermin E suppresses tumor growth by activating anti-tumor …
Gsdme knockout in GSDME-expressing tumors enhances, while ectopic expression in Gsdme-repressed tumors inhibits, tumor growth. Tumor suppression is mediated by cytotoxic …
GSDME- 信号通路|蛋白抗体-华美生物
GSDME在细胞中的作用机制主要是通过被Caspase 3切割激活，诱导细胞从凋亡向细胞焦亡转换。 在生物学上，GSDME具有多重意义，包括参与神经退行性疾病的发生、调节炎症反应，以及 …
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