The role of protein kinase R in the interferon response
The protein kinase R (PKR) is one of the first and best characterized of these effector molecules. PKR mediates responses via phosphorylation of protein substrates and promotes signal …
ADAR1 and PKR, interferon stimulated genes with clashing effects …
2018年4月1日 · ADAR1 enhances HIV-1 replication by inhibiting RNA sensing, by RNA editing and by preventing PKR activation. The induction of hundreds of Interferon Stimulated Genes …
PKR(Protein kinase R)是一种双链RNA 依赖 性蛋白激酶，由IFN-Ⅰ和IFN-Ⅲ诱导高表达，被病 毒dsRNA 等激活后，使其发生自我磷酸化，而活化 的PKR 进一步促进IFN 的产生。随后PKR 通 …
Interferon-stimulated genes and their antiviral effector functions
2011年12月1日 · One interesting property of ISG-mediated antiviral activity is the magnitude with which a single IFN effector can inhibit virus replication. Not surprisingly, the first antiviral ISGs …
XRN1 deletion induces PKR-dependent cell lethality in interferon ...
2024年2月27日 · Here, we show that the exoribonuclease XRN1 is a negative regulator of the dsRNA sensor protein kinase R (PKR) in cancer cells with high interferon-stimulated gene …
Translation inhibition and stress granules in the antiviral immune ...
2017年6月26日 · Double-stranded RNA-activated protein kinase (PKR) is the main sensor protein that detects virus infection and phosphorylates eukaryotic translation initiation...
<br>蛋白激酶 R (PKR) 作为抗病毒先天免疫中的 ... - X-MOL
蛋白激酶 R (PKR) 是一种关键的双链 RNA (dsRNA) 激活传感器，对于细胞对不同刺激的反应至关重要。 该协议描绘了一个综合的方法框架，采用单一荧光素酶测定、酵母测定、免疫印迹测 …
ADAR1 and PKR, interferon stimulated genes with clashing
ADAR1 promotes viral replication by acting as an RNA sensing inhibitor, by editing viral RNA and by inhibiting PKR. This review challenges the orthodox dogma of ISGs as antiviral proteins, by …
Type 1干扰素抗病毒作用机制 - 知乎 - 知乎专栏
ISGs包括PKR；2’-5'-OAS 和RNAse L。PKR识别ds RNA，然后关闭蛋白表达（PKR识别dsRNA被激活，使eIF2磷酸化，然后其不能发挥翻译起始作用）。OAS作用（OAS被dsRNA …
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction
2016年3月3日 · Of note is PKR, an ISG whose activity is triggered by the presence of foreign dsRNA. PKR was initially identified for its ability to inhibit viral protein translation in vaccinia …