2012年2月29日 · In this study, we found that JEV NS2A could antagonize PKR-mediated growth inhibition in a galactose-inducible PKR-expressing yeast system. In human cells, PKR …

2013年9月1日 · The levels of protein kinase R (PKR) was consistently increased in JEV-infected cells than mock-infected cells at all time points. However, it is to be noted that at 24 h post …

2025年2月20日 · In order to define the temporal relationship between the UPR activation and neural stem cell death during JEV infection, our investigation aims to uncover the role of PARP …

本研究旨在探究日本脑炎病毒 (JEV)感染细胞后产生非编码亚基因组RNA (sfRNA)的生物学功能.应用Northern blot检测JEV感染细胞产生sfRNA的动态特征;通过Western blot和qPCR检测JEV感 …

In this study, we found that JEV NS2A could antagonize PKR-mediated growth inhibition in a galactose-inducible PKR-expressing yeast system. In human cells, PKR activation, eIF2α …

Japanese encephalitis virus (JEV) nonstructural protein 5 (NS5) exhibits a Type I interferon (IFN) antagonistic function. This study characterizes Type I IFN antagonism mechanism of NS5 …

实验结果表明:JEV感染Huh7细胞后期可下调PKR、IFITM2的表达,与sfRNA产生的时间规律一致;将体外转录制备的JEV sfRNA转染细胞后可下调IFN-α刺激细胞中IFITM2、PKR蛋白的含量,但 …

The interferon (IFN)-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) phosphorylates the eukaryotic translation initiation factor 2α subunit (eIF2α) after sensing viral …

In JEV, NS2A represses the cellular function of PKR, an antiviral host factor that reduces virus replication and translation [103]. PKR is induced by interferon and activated by dsRNA to …

2012年10月1日 · The interferon (IFN)-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) plays a critical role in host antiviral defense. PKR is an antiviral IFN-stimulated …