X-Ray Crystal Structure and Functional Analysis of Vaccinia Virus K3L ...
2002年2月19日 · The vaccinia virus protein K3L subverts the mammalian antiviral defense mechanism by inhibiting the RNA-dependent protein kinase PKR. K3L is a structural mimic of …
Protein kinase R reveals an evolutionary model for defeating viral ...
2008年11月30日 · To be effective, PKR must recognize a conserved substrate (eIF2α) while avoiding rapidly evolving substrate mimics such as K3L. Using the PKR–K3L system and a …
Rapid evolution of protein kinase PKR alters sensitivity to viral ...
2008年11月30日 · Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2), leading to …
Mechanistic Link between PKR Dimerization, Autophosphorylation…
2005年9月23日 · To gain further insight into the importance of PKR autophosphorylation for specific substrate recognition, we used surface plasmon resonance (SPR) to examine the …
Muta-tional analysis identifies two proximal regions of the K3L structure as possessing specialized PKR binding and inhibitory function. Further analysis reveals that PKR dimerization composes …
RCSB PDB - 1LUZ: Crystal Structure of the K3L Protein From …
2002年5月23日 · The vaccinia virus protein K3L subverts the mammalian antiviral defense mechanism by inhibiting the RNA-dependent protein kinase PKR. K3L is a structural mimic of …
The role of the PKR-inhibitory genes, E3L and K3L, in ... - PubMed
2002年7月20日 · On the contrary, the K3L gene is required for replication in BHK cells, but is dispensable for replication in HeLa cells. Our results suggest that these cell lines varied in the …
Mechanistic Link between PKR Dimerization ... - ScienceDirect
2005年9月23日 · The vaccinia virus K3L protein is a pseudosubstrate inhibitor of PKR. K3L and eIF2α share a β barrel fold originally identified in the ribosomal protein S1 (Dar and Sicheri, …
X-ray crystal structure and functional analysis of vaccinia virus K3L ...
The vaccinia virus protein K3L subverts the mammalian antiviral defense mechanism by inhibiting the RNA-dependent protein kinase PKR. K3L is a structural mimic of PKR's natural substrate, …
The dsRNA protein kinase PKR: Virus and cell control
2007年6月1日 · PKR activation during a viral infection represents a threat for several viruses, which have therefore evolved to express PKR inhibitors, such as the Vaccinia E3L and K3L …