Protein kinase R is an innate immune sensor of proteotoxic stress …
2022年2月11日 · Here, we identified protein kinase R (PKR) as an innate immune sensor for proteotoxic stress. PKR activation was observed in cellular models of decreased proteasome …
Stress leads to IL-24 danger - Science | AAAS
2022年2月11日 · Here, we identified protein kinase R (PKR) as an innate immune sensor for proteotoxic stress. PKR activation was observed in cellular models of decreased proteasome …
Adaptive duplication and genetic diversification of protein kinase …
2022年11月23日 · Here, we have characterized the functional diversification of the protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved …
<br>蛋白激酶 R (PKR) 作为抗病毒先天免疫中的 ... - X-MOL
蛋白激酶 R (PKR) 是一种关键的双链 RNA (dsRNA) 激活传感器，对于细胞对不同刺激的反应至关重要。 该协议描绘了一个综合的方法框架，采用单一荧光素酶测定、酵母测定、免疫印迹测 …
Therapeutic circRNA aptamer alleviates PKR-associated ... - PubMed
5 Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of …
Cell fate determined by the activation balance between PKR and …
2020年8月15日 · Double-stranded RNA (dsRNA)-dependent protein kinase R (PKR) activation via autophosphorylation is the central cellular response to stress that promotes cell death or …
PKR: A Kinase to Remember - PMC - PubMed Central (PMC)
Protein kinase R (PKR) is a serine-threonine kinase (551 amino acid long) encoded in humans by the EIF2AK2 gene [located on chromosome 2 (Feng et al., 1992)], which plays a major role in …
PKR; 用于细胞应激的前哨激酶。,Oncogene - X-MOL
双链RNA（dsRNA）激活的蛋白激酶PKR是一种普遍表达的丝氨酸/苏氨酸蛋白激酶，可被干扰素诱导并被dsRNA，细胞因子，生长因子和应激信号激活。 细胞对各种压力（包括生长因子剥 …
两种蛋白质的故事：PACT 和 PKR 及其在炎症中的作用,The FEBS …
2021年1月2日 · 在众多调节促炎信号传导的蛋白质中，很少有蛋白质激酶 r (pkr) 等已被证明在各种刺激诱发的炎症中发挥着广泛的作用。pkr 最初被定性为一种由病毒双链 rna 激活的干扰素诱 …
Rapid evolution of protein kinase PKR alters sensitivity to viral ...
2008年11月30日 · Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2), leading to …