麦角酸是澳大利亚真菌伯氏曲霉（Aspergillus burnettii）的新型抗生素。 稀有的两亲双链支架由通过26碳链连接到吡咯烷二酮单元的β- d-甘露糖组成。 最丰富的代谢产物显示出强大的体外抗真菌活性。 比较基因组学鉴定了杂合PKS-NRPS bua基因簇，该构象通过构巢曲霉中的异源途径重组得到了证实。 The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii.

The rare bolaamphiphilic scaffold consists of β- d -mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.

2019年3月1日 · Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans. The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii.

2022年11月24日 · Recently, Li and coworkers characterized a gene cluster bua involving in the burnettramic acid generation from Aspergillus burnettii, which revealed that the PKS−NRPS hybrid BuaA and the mannoyltransferase BuaB functioned in the formation of proline-incorporating polyketide aglycone skeleton and β-D-mannose transferring, respectively .

2003年4月1日 · Since the first reports of bacterial type I PKS in 1990 4., 5., type II PKS in 1984 6., 7., and type III PKS in 1999 [8], the PKS paradigms have served the scientific community beyond the call of duty, providing the molecular basis to explain the vast structural diversity observed with polyketide natural products, and the biotechnological ...

2025年1月17日 · Splitting the large busA gene rescues translation of truncated mRNAs into functional PKS subunits, and increases the biosynthetic efficiency of butenyl-spinosyn PKS by 13-fold. The truncated mRNA translation rescue strategy will facilitate engineering of multi-domain proteins to enhance their functions.

The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.

近日，《德国应用化学》（Angewandte Chemie International Edition）发表了武汉大学药学院邓子新院士团队孙宇辉教授课题组在聚酮合酶（Polyketide synthase, PKS）生物合成领域最新研究进展，揭示了PKS结构域可通过...

聚酮化合物（polyketide）是一类来源广泛、结构多样的活性天然产物，聚酮合酶（polyketide synthase， PKS）负责聚酮骨架的生物合成。 细菌次级代谢中PKS广泛存在，不同类型的PKS在组成和生物合成机制上各不相同，从而产生截然不同的聚酮骨架。 根据细菌PKS功能和生物合成途径的不同，可以将其分为Ⅰ型、Ⅱ型和Ⅲ型。 PKS通常能与其他生物合成酶系杂合以产生结构更为复杂的天然产物。 同时，不同类型PKS之间也可以形成多种内部杂合，产生更多样的聚酮骨 …

Notable examples include the PKS-NRPSs involved in the biosynthesis of the burnettramic acids in Aspergillus burnettii [19], the cytochalasins in Aspergillus clavatus [57], and phomacins in ...