Polyketide synthases (PKSs) are a family of multi- domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages. The biosyntheses of polyketides share striking similarities with fatty acid biosynthesis. [1][2]

聚酮合酶(polyketide synthases,PKSs)是完成种类繁多的PKs生物合成的核心催化机器,具有严密、精巧的通用构造和普遍遵循且高效的基本流程,主要通过催化短链的羧酸衍生单元发生的连续的缩合反应来合成PKs,该过程与脂肪酸的生物合成极为相似[1]。

Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and function, has the potential to produce millions of organic molecules.

2007年9月3日 · We describe a system named ASMPKS (Analysis System for Modular Polyketide Synthesis) for computational analysis of PKSs against genome sequences. It also provides overall management of information on modular PKS, including polyketide database construction, new PKS assembly, and chain visualization.

2021年9月4日 · Polyketide synthases (PKS) produce polyketides, a large group of secondary metabolites produced in bacteria, fungi, plants and certain animal families. PKSs have a huge potential to biosynthesize high-value active pharmaceuticals, agrochemicals, biofuels and industrial chemicals, among others.

聚酮化合物（polyketide）是一类来源广泛、结构多样的活性天然产物，聚酮合酶（polyketide synthase， PKS）负责聚酮骨架的生物合成。 细菌次级代谢中PKS广泛存在，不同类型的PKS在组成和生物合成机制上各不相同，从而产生截然不同的聚酮骨架。 根据细菌PKS功能和生物合成途径的不同，可以将其分为Ⅰ型、Ⅱ型和Ⅲ型。 PKS通常能与其他生物合成酶系杂合以产生结构更为复杂的天然产物。 同时，不同类型PKS之间也可以形成多种内部杂合，产生更多样的聚酮骨 …

Recent progress in the understanding of polyketide synthase (PKS) continues to fuel the growth of combinatorial biosynthesis for natural product structural diversity. The structural analysis of many components of PKS, in particular for the modular type I 6-deoxyerythronilide B …

2020年8月3日 · Engineering polyketide synthases (PKS) to produce new metabolites requires an understanding of catalytic points of failure during substrate processing. Growing evidence indicates the thioesterase (TE) domain as a significant bottleneck within engineered PKS systems. We created a series of hybrid PKS …

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2024年3月22日 · 研究人员表示，细菌多模块聚酮合成酶（PKS）是一种巨型酶，可生成多种具有重要治疗作用但合成上具有挑战性的天然产物。 通过对这些酶进行工程改造，可以实现聚酮结构的多样化。 然而，尽管在顺式乙酰转移酶（顺式AT）PKS方面取得了成功，但定制这种大型装配线仍然具有挑战性。 与教科书上的PKS不同，反式-AT PKS具有PKS模块的非凡多样性，并且通常会演化形成混合PKS。 研究人员分析了氨基酸的共同演化，以确定产生功能性PKS的共同模块 …