Phospholipase C, gamma 1, also known as PLCG1 and PLCgamma1, is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation. It is encoded by the PLCG1 gene [5] [6] and is part of the PLC superfamily.

2024年12月25日 · PLCG1 (Phospholipase C Gamma 1) is a Protein Coding gene. Diseases associated with PLCG1 include Immune Dysregulation, Autoimmunity, And Autoinflammation and Otitis Media. Among its related pathways are Prolactin Signaling and Downstream signaling of activated FGFR2.

该基因编码的蛋白质催化磷脂酰肌醇 4,5-二磷酸形成肌醇 1,4,5-三磷酸和甘油二酯。 该反应使用钙作为辅助因子，并在受体介导的酪氨酸激酶激活剂的细胞内转导中发挥重要作用。 例如，当被 Src 激活时，编码的蛋白质会导致 Ras 鸟嘌呤核苷酸交换因子 RasGRP1 转移到高尔基体，并在那里激活 Ras。 此外，该蛋白质已被证明是肝素结合生长因子 1 (酸性成纤维细胞生长因子) 激活的酪氨酸激酶的主要底物。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2008 年 …

Phospholipase C (PLC) γ1 is a critical enzyme regulating NF-κB, ERK, MAPK, and NFAT signalling pathways, yet germline PLCG1 mutation in human disease has not been reported. We aim to investigate the molecular pathogenesis of a PLCG1 activating variant in a patient with immune dysregulation.

The PLCG1 activating variant resulted in enhanced NF-κB and type II interferon pathways in T cells, and hyperactivated NF-κB and type I interferon pathways in monocytes. Treatment with either PLCγ1 inhibitor or Janus kinase inhibitor reversed the upregulated gene expression profile in …

2021年10月25日 · PLCG1 is located on chromosome 20q12-13.1 and encodes phospholipase Cγ, an enzyme that hydrolyzes phosphatidylinositol-4,5-bisphosphate (PtdIns (4,5)P2) into the second messengers diacylglycerol...

2025年1月4日 · Title: Phospholipase Cγ1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients. A computational in silico approach to predict high-risk coding and non-coding SNPs of human PLCG1 gene.

2021年12月1日 · Phospholipase C gamma 1 (PLCγ1) which belongs to phosphoinositide-specific phospholipase C (PLC) family, is activated by many extracellular stimuli including hormones, neurotransmitters, growth factors and modulates several cellular and physiological functions necessary for tumorigenesis such as cell survival, migration, invasion and angiogenesi...

2025年2月8日 · Plcg1 signalling regulates lipopolysaccharide-induced Ptgs2 protein expression in cardiomyocytes. Plcg1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation. The association of PLCgamma1 with complexes containing GIT1 and beta-Pix is essential for its role in integrin-mediated cell spreading and motility.

2024年3月11日 · PLCg1（Phospholipase C gamma 1）是一种重要的酶类蛋白，其作用于细胞膜磷脂酰肌醇，与细胞信号转导、细胞分化以及细胞等过程密切相关。PLCg1的结构特点复杂多样，与其多功能性密切相关，下面将详细介绍PLCg1蛋白的基本信息以及功能结构。 PLCg1蛋白的基 …