
PLK4 - Wikipedia
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. [5] The Drosophila homolog is SAK, the C. elegans …
PLK4: a promising target for cancer therapy - PubMed
PLK4 plays an important role in centrosome amplification and tumor progression. PLK4 inhibitors used alone or in combination with other drugs have shown significant anticancer efficacy, …
PLK4 Gene - GeneCards | PLK4 Protein | PLK4 Antibody
2024年12月25日 · Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading …
Polo-Like Kinase 4’s Critical Role in Cancer Development and …
Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely associated with cancer development. In this review, we depict the DNA, mRNA, and …
PLK4: a promising target for cancer therapy | Journal of Cancer ...
2019年9月6日 · Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates centriole duplication. PLK4 deregulation causes centrosome number abnormalities, mitotic …
Polo-like kinase 4 (Plk4) potentiates - Nature
2023年2月16日 · Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human …
Role of polo-like kinase 4 (PLK4) in epithelial cancers and recent ...
In this review, we discuss the structure, localization and function of PLK4, along with the functional significance of PLK4 in epithelial cancers and some preliminary work suggesting a …
Discovery of Polo-like Kinase 4 Inhibitors for the Treatment
Used alone or in combination with other anticancer drugs in preclinical and clinical studies, PLK4 inhibitors have shown significant efficacy in the treatment of different cancers, demonstrating …
Therapeutic potential of targeting polo-like kinase 4
2024年2月5日 · Polo-like kinase 4 (PLK4), a highly conserved serine/threonine kinase, masterfully regulates centriole duplication in a spatiotemporal manner to ensure the fidelity of centrosome …
Discovery of the First Potent, Selective, and In Vivo Efficacious Polo ...
Polo-like kinase 4 (PLK4) is a master regulator of centriole replication and has been proposed as a therapeutic target for multiple cancers, especially TRIM37-amplified breast cancer.