2024年12月20日 · Sustained lymphocyte migration from blood into lymph nodes (LNs) is important for immune responses. The CC-chemokine receptor-7 (CCR7) ligand CCL21 is required for LN entry but is downregulated during inflammation, and it …

2011年8月31日 · To better understand these observations, we developed longitudinal imaging outcomes of synovitis and lymphatic flow in mouse models of RA, and identified that asymmetric knee flare is associated with ipsilateral popliteal lymph node (PLN) collapse and the translocation of CD23 + /CD21 hi B-cells (B-in) into the paracortical sinus space of the node.

2018年4月12日 · In this study, we developed an advanced surgical method for resection of the PLN to induce ILN-directed lymphatic flow for at least 12 weeks. This model is useful for quantitative analysis of...

2015年2月1日 · Recently, it has been demonstrated in murine models of RA that the popliteal lymph node (PLN) is a biomarker of arthritic flare, as it “expands” in size and contrast enhancement during a prolonged asymptomatic phase, prior to when it “collapses” with accelerated synovitis and joint erosion.

2011年8月31日 · Afferent lymphatic flow to PLN and ILN was quantified by near infrared imaging of injected indocyanine green (NIR-ICG). The B-in population in PLN and ILN was assessed by immunohistochemistry (IHC) and flow cytometry. Linear regression analyses of ipsilateral knee synovial volume and afferent lymphatic flow to PLN and ILN were performed.

The objective of this study was to examine whether removal of a popliteal lymph node (PLN) could result in rerouting of lymph flow and whether a single transplanted nonvascularized lymph node could reconnect with a lymphatic vessel and restore lymph flow.

In order to elucidate the nature of the B cell populations involved in the observed PLN changes, we conducted an extensive analysis of PLNs and other peripheral lymphoid organs (spleen, as well as axillary, iliac and mesenteric lymph nodes – ALN, ILN, MLN, respectively) from hTNF-tg mice and wild-type controls by flow cytometry (summarized in ...

Introduction: Pelvic lymph node (PLN) metastasis has a worse prognosis in penile squamous cell carcinoma. This study sought to determine the predictors of PLN metastasis in penile SCC. Materials and methods: This retrospective study included primary penile resections with inguinal lymph nodes (ILN) and PLN dissections over 10 years (2007-2017).

2016年2月2日 · In a similar homing index assay, pLN lymphocytes from 2 week-old mice migrated efficiently to PP and LP, and less so to iLN and aLN of 5 week-old SPF mice (Figure 6D). However, pLN lymphocytes from 6 week-old mice had lost this ability, instead showed a better migration to pLN than to GALT (Figure 6D). Therefore, our data imply that the ...

2023年8月28日 · 免疫细胞的激活在胰岛中启动，并在淋巴组织中放大，特别是那些胰腺引流淋巴结（pln）。 关于 PLN 作为异常免疫反应中心的知识正在不断得到补充和更新。