EAE（实验性自身免疫性脑脊髓炎）模型建立：PLP 髓鞘蛋白脂质 …
实验性自身免疫性脑脊髓炎（Experimental Autoimmune Encephalomyelitis，EAE）是最常用的实验性动物模型用来研究人炎症脱髓鞘病，多发性硬化病（Multiple sclerosis，MS）。 EAE是 …
Experimental Autoimmune Encephalomyelitis (EAE) - Hooke
In direct EAE (models listed above), disease is induced by immunization with spinal cord homogenate or myelin-derived antigens such as MOG, PLP, or MBP proteins or peptides. …
自身免疫性脑脊髓炎（EAE）动物模型的建立 - 知乎
实验性自身免疫性脑脊髓炎 （experimental autoimmune encephalomyelitis，EAE）是一种以特异性致敏的 CD4+T细胞 介导为主的，以中枢神经系统内小血管周围出现单个核细胞浸润及髓鞘 …
EAE Induction by Active Immunization in SJL Mice
2023年6月4日 · EAE is induced in SJL mice by immunization with an emulsion of PLP 139-151 in complete Freund's adjuvant (CFA). When using EK-2120, the initial immunization is followed …
Experimental Autoimmune Encephalomyelitis in Mice - PMC
Experimental autoimmune encephalitis (EAE), the animal model of multiple sclerosis (MS), has provided significant insight into the mechanisms that initiate and drive autoimmunity. Several …
多发性硬化症(Multiple sclerosis (MS))|实验性自身免疫性脑脊髓炎模型(EAE…
实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis, EAE)是一种以特异性致敏的CD4+T细胞介导为主, 对实验动物进行髓鞘蛋白免疫构建的疾病模型。EAE与人类MS在 …
多发性硬化（MS）模型|百奥赛图官网 - Biocytogen
百奥赛图在野生C57BL/6小鼠和自主开发的B-hIL17A人源化小鼠上建立了MOG诱导的EAE疾病模型，可用于MS相关药物的药效评价。 在10周龄C57BL/6雌性小鼠（n=6）中使用MOG35-55乳 …
Hooke - Contract Research - EAE - PLP139-151/CFA-Induced …
This direct EAE model is induced by immunization with [Ser 140]-PLP 139-151 emulsified in CFA, optionally followed by administration of pertussis toxin (PTX). With or without PTX, EAE …
MBP-PLP fusion protein-induced EAE in C57BL/6 mice - PubMed
Here we are introducing MBP-PLP fusion protein (MP4)-induced EAE for C57BL/6 mice. B cell- and CD8+ T cell-dependence, as well as multi-determinant recognition are among the unique …
【动物造模】小鼠脑脊髓炎EAE - 知乎 - 知乎专栏
PLP是高度疏水的膜蛋白,对PLP不同肽决定簇发生反应的CD4+T细胞能诱导急性、慢性复发型及慢性进展型EAE。 在MS患者体内也发现与PLP抗原决定簇发生反应的T细胞。 最近研究表明,体 …