Interactions of Protein Kinase C-α C1A and C1B Domains with …
2014年8月8日 · The findings of strong nonpolar contacts between PKCα C1B and PMA, reduced contacts between the membrane and the C1B-PMA complex, and abnormally fast diffusion of …
Molecular Interaction Model for the C1B Domain of Protein Kinase …
2004年11月13日 · Detailed molecular models of the free C1B domain of protein kinase C-γ (PKC-γ) and the C1B domain with its activator phorbol-12-myristate-13-acetate (PMA) in water …
Structural determinants of phorbol ester binding activity of the …
2018年5月1日 · In confocal experiments, deletion of the C1b domain from full length PKCθ diminished, whereas deletion of the C1a domain enhanced 5-fold (at 100 nM PMA) the …
Characterization of the Differential Roles of the Twin C1a and C1b ...
2009年1月9日 · Consistent with its potent sensitivity for PMA, the double δC1b (C1b-C1b/PKCδ-GFP) mutant also showed clear dose dependent down-regulation in response to PMA. These …
Comparison of the roles of the C1a and C1b domains of protein …
1999年7月30日 · Octyl-ILV thus resembles PMA in the difference in its C1 domain dependence between PKCα and PKCδ, shifting from dependence primarily on C1b in PKCδ to equivalence …
Contribution of the C1A and C1B domains to the membrane
2003年9月30日 · Novel and conventional protein kinase C isozymes contain a tandem repeat of C1 domains, the C1A and C1B, which each contain a binding pocket for phorbol …
(PDF) Molecular Interaction Model for the C1B Domain of Protein …
Detailed molecular models of the free C1B domain of protein kinase C-γ (PKC-γ) and the C1B domain with its activator phorbol-12-myristate-13-acetate (PMA) in water solution and in the …
either the C1A or C1B domains are mutated so that they are unable to bind PMA, if one moiety of the dimer contains a nonfunctional phorbol, or if the binding to the isolated C1B domain is …
Molecular interaction model for the C1B domain of protein
2004年12月16日 · Detailed molecular models of the free C1B domain of protein kinase C-gamma (PKC-gamma) and the C1B domain with its activator phorbol-12-myristate-13-acetate (PMA) …
PKCeta is localized in the Golgi, ER and nuclear envelope and ...
We show that the cysteine-rich repeat C1b is responsible for its Golgi localization, while for its presence at the ER/nuclear envelope the pseudosubstrate containing fragment coupled to the …