PML, a rare disease of the central nervous system caused by JC polyomavirus (JCV) occurring in immunosuppressed people, is typically fatal unless adaptive immunity is restored. We …

Progressive multifocal encephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV), which occurs in immunocompromised …

Here, we demonstrate the safety and efficacy of allogeneic BKV-CTLs in 2 patients severely affected by PML. Both patients improved clinically and radiologically and generated a specific …

Clinical-grade BKV-specific T cells were isolated from leukapheresis products of suitable donors using the CliniMACS Prodigy device (Miltenyi Biotec), the CliniMACS CCS system IFN-γ …

2018年10月10日 · We performed a phase 2, protocol-driven study, involving three patients with PML, to evaluate whether cryopreserved, third-party–produced, viral-specific T cells that had …

In this study, we investigated the relationship between PML-NBs and BKV during infection of primary human renal proximal tubule epithelial (RPTE) cells. While the levels of the major PML …

2024年9月1日 · JC virus (JCV) reactivation can lead to a life-threatening neurological disease called progressive multifocal leukoencephalopathy (PML) in immunosuppressed patients, …

The only human disease caused by an infection with the human polyomavirus JCV is progressive multifocal leukoencephalopathy (PML) characterized by a lytic infection of oligodendrocytes …

2021年5月17日 · This study provides Class IV evidence that for patients with PML, allogeneic transplant of BKV-CTL improved symptoms, reduced MRI changes, and decreased viral load.

2004年8月1日 · In the present study, we used BrdU pulse labeling to demonstrate that PML-NBs accumulate newly synthesized DNA in cells infected by the polyomaviruses simian virus 40 …