2021年12月10日 · Although PNH cells are readily identified by flow cytometry due to their deficiency of GPI-anchored proteins, the assessment of the clinical significance of a PNH …

2021年12月10日 · Although exceptions occur, bone marrow failure patients usually have smaller, subclinical PNH clones. This review addresses the common scenarios that arise in evaluating …

2021年3月4日 · In this large single-centre study, we report high prevalence (25%) of, small (<10%) and very small (<1%), paroxysmal nocturnal hemoglobinuria (PNH) clones by high …

2021年8月24日 · Our results indicated that PNH and acquired 6p CN-LOH clones encompassing HLA genes have ∽100% positive predictive value for AA, and they can facilitate diagnosis in …

2017年5月18日 · Paroxysmal nocturnal haemoglobinuria is caused by somatic mutations (denoted by white stars) in the X-linked PIGA gene in one or more clones of multipotent...

2012年11月16日 · The presence of paroxysmal nocturnal hemoglobinuria (PNH) clones in the setting of aplastic anemia (AA) and myelodysplastic syndrome (MDS) highlights the …

Objectives: PNH clones, also aptly called "escape clones," are evidence of acquired immune-mediated bone marrow failure and have a high prevalence in patients with aplastic anemia (AA).

Flow cytometric detection of PNH clones has become the gold standard and has played an increasingly important role in the diagnosis, monitoring, and clinical management of patients …

2024年10月1日 · PNH is a clonal hematopoietic stem cell disorder that develops due to somatic mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA) in 1 or …

2024年12月13日 · Studies have suggested that mutations in PIGA lead cells harbouring PNH clones to escape T-cell-mediated autoimmune attack, resulting in resistance to apoptosis and …