
PNPLA3 - Wikipedia
Patatin-like phospholipase domain-containing protein 3 (PNPLA3), also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.
PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated …
2024年6月6日 · Despite showing a triglyceride hydrolase activity in vitro, PNPLA3 has yet to be established as a lipase in vivo. Here, we show that PNPLA3 preferentially hydrolyzes polyunsaturated...
PNPLA3的I148M突变引起非酒精性脂肪肝的机制 - 百度
2023年11月24日 · 近日,来自美国耶鲁大学医学院的Panu K. Luukkonen研究组在Cell Metabolism上发表了文章The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans,该研究报道了PNPLA3 I148M突变体的纯合携带者具有线粒体功能障碍的特征,该类人群肝脏中酮体生成明显增加和脂肪合成 减少;这些结果对开发治疗脂肪肝的精准医学方法具有重要的意义。 PNPLA3是一种主 …
J Hepatol丨脂肪肝机制研究新突破——PNPLA3 (148M)突变通过功 …
2024年11月26日 · 阐明脂质在肝脏中的正常代谢和异常积累的机制是理解脂肪性肝病发生和发展的重要机制性问题及临床转化探索的基础。 PNPLA3 (patatin-like phospholipase domain-con...
PNPLA3 Gene - GeneCards | PLPL3 Protein | PLPL3 Antibody
2024年12月25日 · PNPLA3 (Patatin Like Phospholipase Domain Containing 3) is a Protein Coding gene. Diseases associated with PNPLA3 include Fatty Liver Disease 1 and Megalencephalic Leukoencephalopathy With Subcortical Cysts 2A. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism.
PNPLA3基因在非酒精性脂肪性肝病中的作用
pnpla3位于细胞膜与脂滴之间, 两者紧密联系在一起, 高盐、高ph值等无法将两者分开. pnpla3可能有针对性的存在于内质网新生膜脂滴形成的专门区域. 另外, pnpla3也可能通过内质网转高尔基体转运机制, 从内质网膜转运到脂滴上. pnpla3也可能在膜和脂滴之间执行不同 ...
Global Epidemiology and Implications of PNPLA3 I148M Variant …
PNPLA3 rs738409 variant is a risk factor for onset and progression of metabolic dysfunction–associated steatotic liver disease (MASLD). We aimed to assess its global prevalence, clinical and histological characteristics, and long-term outcomes in …
PNPLA3—A Potential Therapeutic Target for Personalized …
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) is a lipid droplet-associated protein that has been shown to have hydrolase activity toward triglycerides and retinyl esters. The first evidence of PNPLA3 being associated with fatty ...
肝脏与脂肪组织之间的串扰:PNPLA3的新作用?,Liver …
大量证据表明,含有 Patatin 样的磷脂酶结构域3(PNPLA3)rs738409,导致蛋白148(I148M)处的异亮氨酸被蛋氨酸取代,对FLD进程发挥了最强的遗传作用。 PNPLA3是一种具有甘油三酸酯水解酶活性的肝脂肪酶,其148M变体导致该功能丧失,从而阻碍了单和多不饱和脂肪酸的重塑,并有利于它们在肝脏中的保留。 2,3 另外:在肝细胞中,148M功能丧失的变异通过减少VLDL分泌导致脂质积累增加 4; 在星状细胞中,148M功能缺失会导致视黄醇保留,并增 …
The PNPLA family of enzymes: characterisation and biological role
PNPLA3 is located in the cytoplasm and is recruited to lipid droplets in a way similar to PNPLA2 (15, 60−63). In humans, PNPLA3 is highly expressed in hepatocytes and hepatic stellate cells and to a lower extent in the adipose tissue, kidneys, brain, and skin (38, 63).