2024年12月25日 · POU5F1 (POU Class 5 Homeobox 1) is a Protein Coding gene. Diseases associated with POU5F1 include Embryonal Carcinoma and Teratoma . Among its related pathways are Gastrulation and Meiosis .

Oct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded by the POU5F1 gene. [5] Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. [6]

2023年12月7日 · POU5F1 plays an important role in maintaining the cancer stem cell (CSC) -like properties of gastric cancer (GC) cells. The impact of POU5F1 on the proliferation and metastasis of GC was...

POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6. A paradigm for post-embryonic Oct4 re-expression: E7-induced hydroxymethylation regulates Oct4 expression in cervical cancer.

2013年4月3日 · We assayed long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) using 4C-Seq technique. We discovered that their frequent...

2025年2月18日 · Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage. Compression force, which is generated by the 3D-SAC, promotes colony growth and expression of Nanog and Oct4 in mESCs and blastocyst development of mouse embryos.

该基因编码含有 POU 同源结构域的转录因子，该结构域在胚胎发育和干细胞多能性中起着关键作用。 该基因在成人组织中的异常表达与肿瘤发生有关。 该基因可以参与 21 号染色体上尤文氏肉瘤基因的易位，这也导致肿瘤形成。 可变剪接，以及替代 AUG 和非 AUG 翻译起始密码子的使用，导致多种亚型。 AUG 起始密码子之一在人群中具有多态性。 已在 1、3、8、10 和 12 号染色体上鉴定出相关的假基因。 [RefSeq 提供，2013 年 10 月]

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

POU 域转录因子与特定八聚体 DNA 基序结合并调节细胞类型特异性分化途径。 编码的蛋白质在胚胎发育和干细胞多能性中起着关键作用。 可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月] The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways.

Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence. [1] Their DNA-binding domain is a POU domain.. There are eight Octamer proteins in humans (Oct1–11), [2] which have been renamed according to the different classes of POU domain. [3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the ...