2024年2月28日 · Our results show that the PP2A switch is induced by PKC-mediated phosphorylation of Ser24-PP2Ac and that this phosphorylation leads to apoptosis upon …

In the present study, we determined the cross talk between PI3K-AKT-GSK-3β and PP2A pathways and found that the former regulated the methylation of PP2Ac via GSK-3β. …

Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules …

2018年8月1日 · The effects of AKT and SRC inhibitors on pancreatic cancer cell proliferation were investigated. Two human pancreatic cancer cell lines, MIA PaCa-2 and PANC-1, were treated …

2003年1月24日 · PP2 abrogated 17β-estradiol-induced activation of PI3-kinase, indicating that the PP2-inhibitable kinase is upstream of PI3-kinase and Akt. A 17β-estradiol-induced estrogen …

In the present study, the pyrazolopyrimidine compound PP2 was used to inhibit Src family protein tyrosine kinases in A549 cells. It was demonstrated that PP2 was able to suppress cell …

2019年10月1日 · Our findings demonstrate that SNRK regulates insulin signaling through controlling PPP2R5D phosphorylation, which subsequently impacts PP2A activity and then …

One study identified sex-determining region Y box 2 as a novel target of epidermal growth factor receptor (EGFR)/Src/protein kinase B (Akt) signaling in NSCLC that modulates self-renewal …

2021年11月23日 · Immunoblotting demonstrated PP2-sensitive phosphorylation of AKT and the MTORC1 target 4EBP1, suggesting PI3K/AKT activation as a key survival pathway …

In the present study, the pyrazolopyrimidine compound PP2 was used to inhibit Src family protein tyrosine kinases in A549 cells. It was demonstrated that PP2 was able to suppress cell …

2020年12月4日 · Herein, we demonstrate that Aldob suppresses Akt activity and tumor growth through a protein complex containing Aldob, Akt, and protein phosphatase 2A (PP2A), leading …

2022年11月10日 · Here, we show that MASTL/Greatwall, a cell cycle kinase that supports mitosis by phosphorylating the PP2A/B55 inhibitors ENSA/ARPP19, inhibits PI3K‐AKT activity by …

蛋白磷酸酶 2A （PP2A） 是一种必需的抑癌基因，其活性在癌细胞中经常受到 SE 易位 （SET） 等内源性 PP2A 抑制蛋白的阻碍。 SET/PP2A 轴在癌细胞的集落形成能力以及与此过程相关 …

2020年2月2日 · Rescue experiments done with either non-phosphorylatable mutant cofilin-1 (S3A) transfection or an activator of the AKT pathway significantly reversed the inhibition …

pp2a 在异种移植肿瘤模型中抑制肿瘤生长和 vm 形成。pi3k 抑制剂 benc-511 可以增强 pp2a 的激活，从而在体外和体内抑制 p-akt/zeb1 和 vm 的形成。该研究表明，pp2a 可以通过 …

More specifically, in SCC1483 and YD15PP2 HNSCC cell lines, PP2 exposure downregulated Erk, Akt/Slug, and Snail but upregulated E-cadherin. These results suggest that PP2 inhibits …

2008年9月15日 · Our results suggest that the nature of the synergistic interaction between PP2 and 5-FU and the observed chemo-sensitizing effect is most likely associated with the …

Penfluridol treatment decreased phosphorylation at PP2A targets c-MYC, AKT and GSK3β and caused cell death in a PP2A dependent manner. Importantly, penfluridol and the structurally …

3 天之前 · Pulmonary hypertension (PH) is a progressive and life-threatening cardiopulmonary disease that is not uncommon. The modulation of the pulmonary artery (PA) involves various …