Therefore, we reviewed the superfamily of phosphatases and more specifically PP2A, its regulation, and physiological functions participate in CNS. Thereafter, we discussed the latest findings about PP2A dysregulation in Alzheimer and Parkinson diseases and possible interplay between this phosphatase and insulin signaling pathways.

Therefore, we reviewed the superfamily of phosphatases and more specifically PP2A, its regulation, and physiological functions participate in CNS. Thereafter, we discussed the latest findings about PP2A dysregulation in Alzheimer and Parkinson diseases and possible interplay between this phosphatase and insulin signaling pathways.

Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules like Akt, p53, c-Myc and β-catenin. It plays a critical role in cellular processes, such as cell proliferation, signal transduction and apoptosis.

Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways of the central nervous system (CNS) in both physiological and pathological conditions.

2020年11月27日，复旦大学 徐彦辉 课题组和 陈飞 课题组合作在 Science 杂志在线发表题为 Identification of Integrator-PP2A complex (INTAC), an RNA Polymerase II phosphatase 的研究长文（Research Article）。 该项研究 发现了一个全新的转录调控复合物 INTAC （16个亚基，分子量近1.5MDa）， 解析了INTAC的高分辨冷冻电镜结构，揭示了INTAC作为一个双功能酶，同时具备RNA剪切和去磷酸化活性，可去除Pol II的多个CTD磷酸化位点发挥转录抑制功能。 该项研 …

2007年6月15日 · PP2 inhibits the enhanced associations of NR2A or Src with PSD-95 induced by 15 min of reperfusion following brain ischemia (I/R15min) in rat hippocampus. Rats were pretreated with 15 μg of PP2 or PP3 or the same dose of DMSO 30 min before ischemia.

2015年12月15日 · PP2A activation induced significant axon sprouting in the lesioned spinal cord and promoted function recovery after SCI. These findings suggest that PP2A works downstream of EGFR and dephosphorylates CRMP2 after CNS injury. Therefore, therapies targeting PP2A may be effective following SCI.

2001年9月4日 · We report here that a src family tyrosine kinase-specific inhibitor, PP2, enhances neurotransmitter release from PC12 cells and primary cultured neurons. PP2 enhances only Ca 2+-dependent release; it does not affect basal release.

Therefore, we reviewed the superfamily of phosphatases and more specifically PP2A, its regulation, and physiological functions participate in CNS. Thereafter, we discussed the latest findings about PP2A dysregulation in Alzheimer and Parkinson diseases and possible interplay between this phosphatase and insulin signaling pathways.

2019年6月1日 · With this in mind, we assess the evidence to support oxidative stress-mediated regulation of the PP2A system. In this article, we first present an overview of the PP2A system before providing an analysis of the regulation of PP2A by endogenous inhibitors, post translational modification, and miRNA.

2014年12月12日 · Results demonstrated that long-term blockade of SFK activation with PP2 increases locomotor activity at 7, 14, 21 and 28 days post-injury in the Basso, Beattie, and Bresnahan open field test, round and square beam crossing tests.

2007年6月15日 · Transient global brain ischemia was induced by the four-vessel occlusion method. A specific Src family kinase inhibitor PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine) and a PP2 negative control PP3 (4-amino-7-phenylpyrazolo[3,4-d]pyramidine) were infused into rat cerebroventricule 30 min before occlusion.

2022年12月17日 · In this study, we assessed the efficacy of 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d] pyrimidine (PP2), a selective c-Src inhibitor on HSNCC. Nine HNSCC cell lines (SNU1041, Fraud, SNU46, SNU1076, SNU899, SCC1483, YD15, YD9, and YD10-) were screened, and the effects of PP2 were …

PP2 是非受体酪氨酸激酶（nRTK） 的Src-家族酪氨酸激酶的选择性抑制剂。它对ζ链TCR相关蛋白激酶70（ZAP-70）和 Janus激酶 2（JAK2）的选择性>10000 倍。PP2 在体外和体内有效地减少宫颈癌增殖。

2007年6月15日 · A specific Src family kinase inhibitor PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine) and a PP2 negative control PP3 (4-amino-7-phenylpyrazolo[3,4-d]pyramidine) were infused into rat cerebroventricule 30 min before occlusion.

2013年7月10日 · Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules like Akt, p53, c-Myc and β-catenin. It plays a critical role in cellular processes, such as cell proliferation, signal transduction and apoptosis.

PP2 是非受体酪氨酸激酶（nRTK） 的Src-家族酪氨酸激酶的选择性抑制剂。它对ζ链TCR相关蛋白激酶70（ZAP-70）和 Janus激酶 2（JAK2）的选择性>10000 倍。PP2 在体外和体内有效地减少宫颈癌增殖。

Our findings demonstrated that PP2 inhibited the cell growth and progression in HNSCC via regulation of epithelial–mesenchymal transition. The head and neck cancers (HNCs) occurring in the nasal area, paranasal sinuses, oral cavity, salivary glands, pharynx, and larynx are collectively referred to as head and neck squamous cell carcinoma (HNSCC).